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Active Motif
Histone macroH2A1 Polyclonal Antibody
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Product Details
39593
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
This Histone macroH2A1 antibody was raised against recombinant protein corresponding to the N-terminal half of mouse macroH2A1.2, so will react with macroH2A1 and the macroH2A1.1 and macroH2A1.2 isoforms.
Conjugate
Form
Liquid
Concentration
Conc. Not Determined
Storage buffer
whole serum with 30% glycerol
Contains
0.035% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H4 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Core histone macro-H2A.1; H2A histone family member Y; H2A.y; H2A/y; Histone H2A.y; Histone macroH2A1; histone macroH2A1.1; histone macroH2A1.2; MACROH2A1.2; Medulloblastoma antigen MU-MB-50.205; unnamed protein product
Gene Aliases: H2A.y; H2A/y; H2AF12M; H2AFY; MACROH2A1; MACROH2A1.1; macroH2A1.2; mH2A1
UniProt ID: (Mouse) Q9QZQ8, (Human) O75367
Entrez Gene ID: (Mouse) 26914, (Human) 9555
rDNA binding
RNA polymerase II regulatory region sequence-specific DNA binding
RNA polymerase II core promoter sequence-specific DNA binding
core promoter sequence-specific DNA binding
DNA binding
chromatin binding
double-stranded methylated DNA binding
protein kinase binding
protein serine/threonine kinase inhibitor activity
chromatin DNA binding
nucleosomal DNA binding
transcription regulatory region DNA binding
protein heterodimerization activity
transcription regulatory region sequence-specific DNA binding
protein binding
enzyme binding
structural constituent of chromatin
ADP-D-ribose binding
ADP-D-ribose modification-dependent protein binding
poly-ADP-D-ribose modification-dependent protein binding
promoter-specific chromatin binding
histone
negative regulation of transcription from RNA polymerase II promoter
nucleosome assembly
dosage compensation
chromatin modification
regulation of lipid metabolic process
negative regulation of histone phosphorylation
regulation of gene expression, epigenetic
positive regulation of keratinocyte differentiation
negative regulation of gene expression, epigenetic
positive regulation of gene expression, epigenetic
negative regulation of histone H3-K4 methylation
negative regulation of histone H3-K27 methylation
establishment of protein localization to chromatin
negative regulation of protein serine/threonine kinase activity
negative regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter
negative regulation of cell cycle G2/M phase transition
regulation of oxidative phosphorylation
DNA repair
chromatin organization
dosage compensation by inactivation of X chromosome
heterochromatin assembly
positive regulation of maintenance of mitotic sister chromatid cohesion
regulation of chromatin silencing at rDNA
protein poly-ADP-ribosylation
regulation of NAD metabolic process
regulation of response to oxidative stress
negative regulation of response to oxidative stress
positive regulation of response to oxidative stress
positive regulation of endodermal cell differentiation
negative regulation of protein localization to chromosome, telomeric region
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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