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Invitrogen
IA-1 Polyclonal Antibody
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Product Details
PA5-40471
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Immunogen peptide is a 14 amino acid sequence within the following: PAAALRPPGK RPPPPTAAEP PAKAVKAPGA KKPKAIRKLH FEDEVTTSPV (aa 191-240).
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
PBS with 2% sucrose
Contains
0.09% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Peptide sequence: PAAALRPPGK RPPPPTAAEP PAKAVKAPGA KKPKAIRKLH FEDEVTTSPV
Sequence homology: Cow: 100%; Dog: 100%; Horse: 79%; Human: 100%; Mouse: 100%; Pig: 100%; Rabbit: 79%; Rat: 79%; Zebrafish: 93%
Target Information
IA-1, also known as INSM1, is an essential five zinc-finger transcription factor that while initially identified from an insulinoma cDNA library, is expressed in the developing nervous system. Specifically, IA-1 is expressed as early as E9.5 in mice in the fore-, mid- and hindbrain, spinal cord, retina, and olfactory bulb. It is thought that IA-1 functions as a transcriptional repressor, and is a part of several signaling pathways including those of Notch and sonic hedgehog in addition to that of Ngn3 during pancreatic endocrine cell differentiation. IA-1 is also expressed in multiple tumors, including the majority of neuroendocrine tumors tested so far as well as nearly 100% of all small cell lung carcinomas, indicating that IA-1 may be an important target in cancer therapy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: IA-1; insulinoma-associated 1; Insulinoma-associated protein 1; Zinc finger protein IA-1
Gene Aliases: IA-1; IA1; INSM1
UniProt ID: (Human) Q01101
Entrez Gene ID: (Human) 3642
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
zinc ion binding
cyclin binding
chromatin DNA binding
histone deacetylase binding
metal ion binding
binding, bridging
negative regulation of transcription from RNA polymerase II promoter
negative regulation of protein phosphorylation
type B pancreatic cell differentiation
pancreatic A cell differentiation
type B pancreatic cell development
noradrenergic neuron development
nervous system development
cell proliferation
positive regulation of cell proliferation
negative regulation of cell proliferation
regulation of gene expression
regulation of cell cycle process
cell migration
cell differentiation
neuron differentiation
positive regulation of cell migration
endocrine pancreas development
endocrine system development
regulation of cell proliferation
norepinephrine biosynthetic process
regulation of protein complex assembly
positive regulation of cell differentiation
regulation of cell cycle
transdifferentiation
adrenal chromaffin cell differentiation
sympathetic ganglion development
positive regulation of neural precursor cell proliferation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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