ICAM-2 is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein. ICAM-2 may play a role in lymphocyte recirculation by blocking LFA-1-dependent cell adhesion. It mediates adhesive interactions important for antigen-specific immune response, NK-cell mediated clearance, lymphocyte recirculation, and other cellular interactions important for immune response and surveillance. Several transcript variants encoding the same protein have been found for this gene. Diseases associated with ICAM2 include Colon Carcinoma In Situ.
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Protein Aliases: CD102; ICAM-2; Intercellular adhesion molecule 2; Lymphocyte function-associated AG-1 counter-receptor; RP23-418O11.10-001
Gene Aliases: CD102; Icam-2; Icam2; Ly-60
UniProt ID: (Mouse) P35330
Entrez Gene ID: (Mouse) 15896