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Invitrogen

ID2 Polyclonal Antibody

1 Published Figure
1 Reference
View all (19) ID2 antibodies

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ID2 Polyclonal Antibody

Product Details

PA5-49683

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,000
View 1 publication 1 publication
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Peptide sequence around aa.5~9(S-P-V-R-S) derived from Human Id2.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2635136

Product Specific Information

The antibody detects endogenous level of total ID2 protein.

Target Information

The inhibitor of DNA binding 2 (ID2) protein is essential for promoting the development of a number of cell types including natural killer cell, erythroid precursors, as well as, CD8+ and CD4+ T-cell. A lack of ID2 promotes B-cell development. The chief role of this protein is to associate with ubiquitously-expressed E proteins, and other proteins of the basic helix-loop-helix (HLH) family, preventing them from binding to DNA and activating transcription. Activation of ID2 is critical for the development of the natural killer cell lineage.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: bHLHb26; cell growth-inhibiting gene 8; Class B basic helix-loop-helix protein 26; DNA-binding protein inhibitor ID-2; DNA-binding protein inhibitor ID2; helix-loop-helix protein ID2; Id-2; Inhibitor of differentiation 2; Inhibitor of DNA binding 2; Inhibitor of DNA binding 2, dominant negative helix-loop-helix protein; inhibitor of DNA binding 2, HLH protein; MGC26389; OTTHUMP00000140258; OTTHUMP00000200297; unnamed protein product

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Gene Aliases: Ac2-300; AI255428; BHLHB26; C78922; GIG8; Id-2; ID2; ID2A; ID2H; Idb2

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UniProt ID: (Human) Q02363, (Rat) P41137, (Mouse) P41136

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Entrez Gene ID: (Human) 3398, (Rat) 25587, (Mouse) 15902

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Function(s)
transcription corepressor activity protein binding ion channel binding protein dimerization activity RNA polymerase II sequence-specific DNA binding transcription factor binding transcription regulator inhibitor activity protein heterodimerization activity DNA-binding transcription factor
Process(es)
negative regulation of transcription from RNA polymerase II promoter metanephros development natural killer cell differentiation thigmotaxis leukocyte differentiation membranous septum morphogenesis bundle of His development regulation of transcription from RNA polymerase II promoter heart development circadian rhythm adult locomotory behavior entrainment of circadian clock regulation of gene expression positive regulation of gene expression negative regulation of gene expression oligodendrocyte development regulation of lipid metabolic process olfactory bulb development neuron differentiation B cell differentiation erythrocyte differentiation circadian regulation of gene expression mammary gland epithelial cell proliferation regulation of circadian rhythm entrainment of circadian clock by photoperiod enucleate erythrocyte differentiation negative regulation of sequence-specific DNA binding transcription factor activity locomotor rhythm negative regulation of B cell differentiation positive regulation of fat cell differentiation positive regulation of erythrocyte differentiation positive regulation of macrophage differentiation regulation of neuron differentiation negative regulation of osteoblast differentiation positive regulation of blood pressure negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated cell development cell maturation rhythmic process Peyer's patch development embryonic digestive tract morphogenesis positive regulation of smooth muscle cell proliferation neuron fate commitment cell morphogenesis involved in neuron differentiation astrocyte differentiation oligodendrocyte differentiation positive regulation of astrocyte differentiation negative regulation of oligodendrocyte differentiation white fat cell differentiation negative regulation of muscle cell differentiation adipose tissue development mammary gland alveolus development epithelial cell differentiation involved in mammary gland alveolus development endodermal digestive tract morphogenesis cellular response to lithium ion dopaminergic neuron differentiation cellular senescence negative regulation of dopaminergic neuron differentiation regulation of G1/S transition of mitotic cell cycle regulation of neural precursor cell proliferation transcription, DNA-templated positive regulation of cell proliferation negative regulation of DNA binding negative regulation of neuron differentiation positive regulation of cell cycle positive regulation of cell cycle arrest negative regulation of neural precursor cell proliferation regulation of transcription, DNA-templated multicellular organism development lymph node development
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