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Fabgennix
IFI6 Polyclonal Antibody, FITC
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Product Details
IFI6-FITC
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide take within amino acid region 80-130 on human Interferon alpha-inducible protein 6.
Conjugate
Excitation/Emission Max
498/517 nm
View spectra
Form
Liquid
Concentration
0.5-1.5 mg/mL
Purification
Affinity chromatography
Storage buffer
proprietary buffer, pH 7.4-7.8, with 30% glycerol, 0.5% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C, store in dark
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
G1P3, also known as Interferon alpha-inducible protein 6 (IFI6) and Interferon-induced protein 6-16, is a 130 amino acid member of the IFI6 family of proteins. Localized to the mitochondria, G1P3 is a multi-pass membrane protein that is induced by IFN-α2β. G1P3 has been shown to play a major role in the apoptosis pathway. Specifically, G1P3 acts as a cell survival protein by inhibiting caspase-3 activity, which antagonizes apoptosis. G1P3 has been implicated in tumorigenesis and is the subject of therapeutic studies, as reducing G1P3-mediated antiapoptotic signals could suggest improved therapies for myeloma or other malignancies.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Ifi-6-16; Interferon alpha-inducible protein 6; interferon, alpha-inducible protein clone IFI-6-16; Interferon-induced protein 6-16; unnamed protein product; Vbeta 13 S3-EQGLLSTDTQYF-Jbeta 2.3
Gene Aliases: 6-16; FAM14C; G1P3; IFI-6-16; IFI6; IFI616
UniProt ID: (Human) P09912
Entrez Gene ID: (Human) 2537
immune system process
apoptotic process
immune response
regulation of epidermal growth factor receptor signaling pathway
negative regulation of apoptotic process
innate immune response
defense response to virus
negative regulation of mitochondrial depolarization
reactive oxygen species metabolic process
negative regulation of release of cytochrome c from mitochondria
intrinsic apoptotic signaling pathway
cellular response to virus
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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