This Antibody was verified by Cell treatment to ensure that the antibody binds to the antigen stated. View Details
PA3-848 detects ISG56 (p56) from human and mouse samples.
PA3-848 has been successfully used in Western blot and ICC/IF applications to detect a 39-58 kDa band.
Interferon-induced antiviral RNA-binding protein that specifically binds single-stranded RNA bearing a 5'-triphosphate group (PPP-RNA), thereby acting as a sensor of viral single-stranded RNAs and inhibiting expression of viral messenger RNAs. Single-stranded PPP-RNAs, which lack 2'-O-methylation of the 5' cap and bear a 5'-triphosphate group instead, are specific from viruses, providing a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Directly binds PPP-RNA in a non-sequence-specific manner. Viruses evolved several ways to evade this restriction system such as encoding their own 2'-O-methylase for their mRNAs or by stealing host cap containing the 2'-O-methylation (cap snatching mechanism). Exhibits antiviral activity against several viruses including human papilloma and hepatitis C viruses.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: GARG-16; Glucocorticoid-attenuated response gene 16 protein; IFI-56K; IFIT-1; IFIT1; interferon, alpha-inducible protein (MW 56kD); Interferon-induced 56 kDa protein; Interferon-induced protein with tetratricopeptide repeats 1; interferon-inducible mRNA 561
Gene Aliases: C56; G10P1; Garg16; IFI-56; IFI-56K; IFI56; IFIT-1; IFIT1; IFNAI1; ISG56; P56; RNM561