Search
Bioss
IFN-beta Polyclonal Antibody
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Additional Information:
{{banner.description}}
FIGURE: 1 / 2
IFN-beta Antibody (BS-0787R) in IHC (P)
Paraformaldehyde-fixed, paraffin embedded human colon carcinoma tissue; Antigen retrieval by boiling in sodium citrate buffer(pH6) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 30 minutes; Blocking buffer (normal goat serum) at 37°C for 20min; Antibody incubation with Rabbit Anti-IFN-beta Polyclonal Antibody, Unconjugated (bs-0787R) at 1:500 overnight at 4°C, followed by a conjugated se... View More
Product Details
BS-0787R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human IFN-beta, amino acids 101-187.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Type I Interferons (IFN-alpha/beta) are produced primarily in response to viral infection by Natural IFN-producing cells (IPCs) as part of the host immune response. IFNs can also inhibit the development of tumors. IFN-beta binding results in the activation of the tyrosine kinases Jak1 and Tyk2, phosphorylation of members of the STAT family of transcription factors, and the transcription and expression of the immune response genes. More recently, several members of the toll-like receptor (TLR) family were found to stimulate the production IFN-beta. IFN-beta is currently used clinically for treatment of tumors, infections and multiple sclerosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: Fibroblast interferon; IFN b; IFN β; IFN-beta; IFNbeta; IFNβ; Interferon; Interferon b; Interferon beta; interferon, beta 1; interferon, beta 1, fibroblast; interferon-beta; RP11-113D19.1; unnamed protein product
Gene Aliases: IFB; IFF; IFN-beta; IFNB; IFNB1
UniProt ID: (Human) P01574, (Rat) P70499
Entrez Gene ID: (Human) 3456, (Rat) 24481
adaptive immune response
T cell activation involved in immune response
B cell activation involved in immune response
natural killer cell activation involved in immune response
negative regulation of immune system process
regulation of transcription from RNA polymerase II promoter
response to stress
defense response
immune response
humoral immune response
signal transduction
cell surface receptor signaling pathway
JAK-STAT cascade
response to virus
positive regulation of metabolic process
positive regulation of autophagy
cytokine-mediated signaling pathway
natural killer cell activation
cellular response to interferon-beta
B cell proliferation
response to exogenous dsRNA
negative regulation of viral genome replication
innate immune response
positive regulation of innate immune response
leukocyte activation
regulation of MHC class I biosynthetic process
negative regulation of T cell differentiation
positive regulation of transcription from RNA polymerase II promoter
negative regulation of multicellular organismal process
defense response to virus
type I interferon signaling pathway
neuron cellular homeostasis
cellular response to dsRNA
cellular response to exogenous dsRNA
receptor signaling pathway via STAT
cellular response to virus
negative regulation of Lewy body formation
antiviral innate immune response
positive regulation of protein localization to nucleus
negative regulation of T-helper 2 cell cytokine production
positive regulation of apoptotic signaling pathway
B cell differentiation
positive regulation of peptidyl-serine phosphorylation of STAT protein
defense response to bacterium
cellular response to dexamethasone stimulus
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support