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Invitrogen

IGF2 Polyclonal Antibody

View all (23) IGF2 antibodies

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IGF2 Polyclonal Antibody

Product Details

PA5-106909

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human IGF2(Accession P01344), corresponding to amino acid residues E30-L80.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2854573

Product Specific Information

Antibody detects endogenous levels of total IGF2.

Target Information

The IGFs are mitogenic, polypeptide growth factors that stimulate the proliferation and survival of various cell types, including muscle, bone, and cartilage tissue in vitro. IGFs are predominantly produced by the liver, although a variety of tissues produce the IGFs at distinctive times. The IGFs belong to the Insulin gene family, which also contains insulin and relaxin. The IGFs are similar to insulin by structure and function, but have a much higher growth-promoting activity than insulin. IGF-II expression is influenced by placenta lactogen, while IGF-I expression is regulated by growth hormone. Both IGF-I and IGF-II signal through the tyrosine kinase type I receptor (IGF-IR), but IGF-II can also signal through the IGF-II/Mannose-6-phosphate receptor. Mature IGFs are generated by proteolytic processing of inactive precursor proteins, which contain N-terminal and C-terminal propeptide regions.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: FLJ22066; FLJ44734; GIG44; H-IGF-2; IGF; IGF-II; Insulin like growth factor; Insulin-like growth factor 2; insulin-like growth factor 2 (somatomedin A); Insulin-like growth factor II; insulin-like growth factor II (IGF-II); Insulin-like growth factor II (somatomedin A); insulin-like growth factor II isoform 2 variant 4 preprotein; insulin-like growth factor II precursor; insulin-like growth factor type 2; insulin-like growth factor-II; MSA; Multiplication-stimulating activity; Multiplication-stimulating polypeptide; preproinsulin-like growth factor II, domains A-E; preptin; somatomedin A; Somatomedin-A; T3M-11-derived growth factor; unnamed protein product

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Gene Aliases: AL033362; C11orf43; GRDF; IGF-2; IGF-II; IGF2; IGFII; M6pr; Mpr; Peg2; PP1446; PP9974; RNIGF2; SRS3

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UniProt ID: (Human) P01344, (Rat) P01346, (Mouse) P09535

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Entrez Gene ID: (Human) 3481, (Rat) 24483, (Mouse) 16002

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Function(s)
insulin receptor binding insulin-like growth factor receptor binding integrin binding hormone activity protein binding growth factor activity transmembrane receptor protein tyrosine kinase activator activity protein serine/threonine kinase activator activity receptor agonist activity receptor activator activity growth factor
Process(es)
negative regulation of transcription from RNA polymerase II promoter ossification osteoblast differentiation in utero embryonic development embryonic placenta development glucose metabolic process regulation of transcription, DNA-templated positive regulation of cell proliferation insulin receptor signaling pathway organ morphogenesis exocrine pancreas development positive regulation of multicellular organism growth positive regulation of activated T cell proliferation positive regulation of MAPK cascade positive regulation of glycogen biosynthetic process positive regulation of mitotic nuclear division positive regulation of transcription from RNA polymerase II promoter positive regulation of organ growth positive regulation of insulin receptor signaling pathway insulin-like growth factor receptor signaling pathway positive regulation of skeletal muscle tissue growth striated muscle cell differentiation regulation of muscle cell differentiation negative regulation of muscle cell differentiation positive regulation of cell division positive regulation of protein kinase B signaling embryonic placenta morphogenesis genetic imprinting positive regulation of vascular endothelial cell proliferation positive regulation of protein phosphorylation female pregnancy memory cell proliferation response to radiation response to organic cyclic compound response to nutrient levels response to estradiol response to nicotine insulin receptor signaling pathway via phosphatidylinositol 3-kinase wound healing response to drug positive regulation of catalytic activity response to ethanol negative regulation of natural killer cell mediated cytotoxicity positive regulation of peptidyl-tyrosine phosphorylation cellular response to mechanical stimulus positive regulation of protein serine/threonine kinase activity positive regulation of steroid hormone biosynthetic process positive regulation of receptor activity positive regulation of glycogen (starch) synthase activity carbohydrate metabolic process
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