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Invitrogen
IGHMBP2 Polyclonal Antibody
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Product Details
PA5-68168
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthesized peptide derived from human IGHMBP2.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Predicted to react with Mouse and Rat samples.
Target Information
5' to 3' helicase that unwinds RNA and DNA duplices in an ATP-dependent reaction. Acts as a transcription regulator. Required for the transcriptional activation of the flounder liver-type antifreeze protein gene. Exhibits strong binding specificity to the enhancer element B of the flounder antifreeze protein gene intron. Binds to the insulin II gene RIPE3B enhancer region. May be involved in translation. DNA-binding protein specific to 5'-phosphorylated single-stranded guanine-rich sequence related to the immunoglobulin mu chain switch region. Preferentially binds to the 5'-GGGCT-3' motif. Interacts with tRNA-Tyr. Stimulates the transcription of the human neurotropic virus JCV.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: AEP; antifreeze enhancer-binding protein; Antifreeze enhancer-binding protein ortholog; ATP-dependent helicase IGHMBP2; cardiac transcription factor 1; DNA-binding protein SMUBP-2; GF-1; Glial factor 1; Immunoglobulin mu-binding protein 2; immunoglobulin S mu binding protein 2; neuromuscular degeneration; p110 subunit; zinc finger, AN1-type domain 7
Gene Aliases: AEP; CATF1; CMT2S; HCSA; HMN6; IGHMBP2; nmd; RIPE3b1; sma; SMARD1; Smbp-2; SMBP2; SMUBP2; ZFAND7
UniProt ID: (Human) P38935, (Rat) Q9EQN5
Entrez Gene ID: (Human) 3508, (Mouse) 20589, (Rat) 29532
tRNA binding
DNA binding
DNA helicase activity
single-stranded DNA binding
RNA binding
protein binding
ATP binding
DNA-dependent ATPase activity
transcription factor binding
RNA-dependent ATPase activity
zinc ion binding
ATP-dependent 5'-3' RNA helicase activity
ribosome binding
ATP-dependent 5'-3' DNA helicase activity
nucleotide binding
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
nucleic acid binding
helicase activity
hydrolase activity
metal ion binding
protein self-association
DNA metabolism protein
DNA replication
DNA repair
DNA recombination
transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
translation
DNA duplex unwinding
protein homooligomerization
negative regulation of transcription from RNA polymerase II promoter
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
spinal cord motor neuron differentiation
metabolic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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