Immunogen sequence: GCFPAGAQVR LESGARVALS AVRPGDRVLA MGEDGSPTFS DVLIFLDREP HRLRAFQVIE TQDPPRRLAL TPAHLLFTAD NHTEPAARFR ATFASHVQPG QYVLVAGVPG LQPARVAAVS THVALGAYAP LTKHGTLVVE DVVASCFAAV ADHHLAQLAF WPLRLFHSLA WGSWTPGEGV HWYPQLLYRL GRLLLEEGSF HPLGMSGAGS; Positive Samples: Human placenta, Mouse kidney, Mouse liver, Mouse ovary, Rat liver, Rat lung, Rat brain; Cellular Location: Cell membrane, Extracellular side, Lipid-anchor, extracellular space
Ihh encodes a member of the hedgehog family of secreted signaling molecules. Hedgehog proteins are essential regulators of a variety of developmental processes including growth, patterning and morphogenesis. The encoded protein specifically plays a role in bone growth an differentiation. Mutations in this gene are the cause of brachydactyly type A1 which is characterized by shortening or malformation of the phalanges. Mutations in this gene are also the cause of acrocapitofemoral dysplasia.
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Protein Aliases: HHG-2; IHH; Indian hedgehog homolog; Indian hedgehog protein; Indian hedgehog protein C-product; Indian hedgehog protein N-product
Gene Aliases: BDA1; HHG2; IHH