A suggested positive control is A-20 cell lysate.
PA5-20286 can be used with blocking peptide PEP-0404.
The protein encoded by this gene is a scaffold protein and a regulator for 3 different kinases involved in proinflammatory signaling. This encoded protein can bind NF-kappa-B-inducing kinase (NIK) and IKKs through separate domains and assemble them into an active kinase complex. Mutations in this gene have been associated with familial dysautonomia.
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Protein Aliases: DKFZp781H1425; elongator acetyltransferase complex subunit 1; Elongator complex protein 1; ELP1; FLJ12497; IkappaB kinase complex-associated protein; IKK complex-associated protein; IKK-complex-associated protein IKAP; inhibitor of kappa light polypeptide enhancer in B-cells, kinase complex-associated protein; p150; RP11-3J11.4
Gene Aliases: 3110040G09Rik; 6030413P05; C78473; DYS; ELP1; FD; IKAP; IKBKAP; IKI3; TOT1