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IKK gamma Polyclonal Antibody
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FIGURE: 1 / 3
IKK gamma Antibody (BS-22575R) in IHC (P)
Paraformaldehyde-fixed, paraffin embedded Human colon cancer; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30 min; Antibody incubation with IKK gamma Polyclonal Antibody, Unconjugated (bs-22575R) at 1:200 overnight at 4°C, DAB staining.
Product Details
BS-22575R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human IKK gamma
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
TBS, pH 7.4, with 50% glycerol, 1% BSA
Contains
0.03% ProClin 300
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
IKK gamma is the regulatory subunit of the inhibitor of the kappaB kinase (IKK) complex, which activates NF-kappaB resulting in activation of genes involved in inflammation, immunity, cell survival, and other pathways. Mutations in this gene result in incontinentia pigmenti, hypohidrotic ectodermal dysplasia, and several other types of immunodeficiencies. Multiple transcript variants encoding different isoforms have been found for this gene. A pseudogene highly similar to this locus is located in an adjacent region of the X chromosome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 14.7K (adenovirus E3 protein) interacting protein 3; FIP-3; gikk; I-kappa-B kinase subunit gamma; ikB kinase subunit gamma; IkB kinase-associated protein 1; IKK3; IKKAP1; incontinentia pigmenti; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma; inhibitor of nuclear factor kappa B kinase subunit gamma; Inhibitor of nuclear factor kappa-B kinase subunit gamma; mF; NEMO; NF-kappa-B essential modifier; NF-kappa-B essential modulator; NF-kB essential modulator; OTTHUMP00000207079; OTTHUMP00000212188
Gene Aliases: AMCBX1; EDAID1; FIP-3; FIP3; Fip3p; IKBKG; IKK-gamma; IKKAP1; IKKG; IMD33; IP; IP1; IP2; IPD2; NEMO; SAIDX; ZC2HC9
UniProt ID: (Human) Q9Y6K9
Entrez Gene ID: (Human) 8517
protein binding
zinc ion binding
protein domain specific binding
polyubiquitin binding
ubiquitin protein ligase binding
signaling adaptor activity
identical protein binding
protein homodimerization activity
metal ion binding
protein heterodimerization activity
K63-linked polyubiquitin binding
linear polyubiquitin binding
transferrin receptor binding
B cell homeostasis
regulation of transcription from RNA polymerase II promoter
apoptotic process
inflammatory response
immune response
cellular response to DNA damage stimulus
I-kappaB kinase/NF-kappaB signaling
response to virus
positive regulation of gene expression
positive regulation of macroautophagy
defense response to bacterium
positive regulation of I-kappaB kinase/NF-kappaB signaling
negative regulation of I-kappaB kinase/NF-kappaB signaling
anoikis
innate immune response
positive regulation of transcription from RNA polymerase II promoter
T cell receptor signaling pathway
positive regulation of T cell receptor signaling pathway
positive regulation of NF-kappaB transcription factor activity
establishment of vesicle localization
protein-containing complex assembly
negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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