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Invitrogen
IKZF3 Polyclonal Antibody
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FIGURE: 1 / 2
IKZF3 Antibody (720418) in ICC/IF
For immunofluorescence analysis, K562 cells were fixed and permeabilized for detection of endogenous IKZF3 using Anti- IKZF3 Rabbit Polyclonal Antibody (Product # 720418, 5 µg/mL) and labeled with Goat anti-Rabbit IgG (Heavy Chain) Superclonal™ Secondary Antibody, Alexa Fluor® 488 conjugate (Product # A27034, 1:2000). Panel a) shows representative cells that were stained for detection and localization of IKZF3 protein (green), Panel b) is stained for nuclei (blue) using SlowFade® Gold Antifade Mountant with DAPI (Product # S36938). Panel c... View More
Product Details
720418
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Protein corresponding to human IKZF3 [aa1-aa120]
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Protein G
Storage buffer
PBS, pH 7.4, with 30% glycerol, 0.1% BSA
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This antibody is predicted to react with Monkey, Rabbit, Dog, Pig.
Target Information
This gene encodes a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development. This gene product is a transcription factor that is important in the regulation of B lymphocyte proliferation and differentiation. Both Ikaros and Aiolos can participate in chromatin remodeling. Regulation of gene expression in B lymphocytes by Aiolos is complex as it appears to require the sequential formation of Ikaros homodimers, Ikaros/Aiolos heterodimers, and Aiolos homodimers. At least six alternative transcripts encoding different isoforms have been described.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Ikaros family zinc finger protein 3; unnamed protein product; zinc finger DNA binding protein Aiolos; Zinc finger protein Aiolos; zinc finger protein, subfamily 1A, 3 (Aiolos); zinc-finger transcription factor
Gene Aliases: AIO; AIOLOS; IKZF3; IMD84; ZNFN1A3
UniProt ID: (Human) Q9UKT9
Entrez Gene ID: (Human) 22806
RNA polymerase II regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
protein binding
zinc ion binding
identical protein binding
protein homodimerization activity
histone deacetylase binding
sequence-specific DNA binding
metal ion binding
protein heterodimerization activity
promoter-specific chromatin binding
regulation of transcription from RNA polymerase II promoter
mesoderm development
response to bacterium
B cell differentiation
T cell differentiation
regulation of B cell proliferation
B cell activation
regulation of apoptotic process
regulation of B cell differentiation
regulation of lymphocyte differentiation
positive regulation of transcription from RNA polymerase II promoter
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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