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|Tested species reactivity||Bovine|
|Published species reactivity||Bovine|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Recombinant IL-1 beta|
|Storage Conditions||4° C|
|Tested Applications||Dilution *|
|ELISA (ELISA)||Assay Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
|ELISA (ELISA)||See 1 publications below|
PBOIL1BI targets IL-1 beta in ELISA applications and shows reactivity with Bovine samples.
The PBOIL1BI immunogen is recombinant IL-1 beta.
PBOIL1BI detects IL-1 beta which has a predicted molecular weight of approximately 18 kDa.
The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bovine intramammary Escherichia coli challenge infections in late gestation demonstrate a dominant antiinflammatory immunological response.
PBOIL1BI was used in ELISA to investigate the inflammatory response to a bovine intramammary challenge with a persistent strain of Escherichia coli during late gestation
|Quesnell RR,Klaessig S,Watts JL,Schukken YH||Journal of dairy science (95:117)||2012|
IL-1 beta; IL-1beta; interleukin-1 beta