In direct ELISAs, approximately 30% cross-reactivity with recombinant human IL-18 is observed and 10% cross-reactivity with recombinant rat IL-18 and recombinant mouse IL-18 is observed.
Reconstitute at 0.2 mg/mL in sterile PBS.
The protein encoded by this gene is a proinflammatory cytokine. This cytokine can induce the IFN-gamma production of T cells. The combination of this cytokine and IL12 has been shown to inhibit IL4 dependent IgE and IgG1 production, and enhance IgG2a production of B cells. IL-18 binding protein can specifically interact with this cytokine, and thus negatively regulate its biological activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: IFN-gamma-inducing factor; IGIF; IL-1 gamma; IL-18; IL-1g; IL18; IL1F4; Interferon gamma-inducing factor; interferon-gamma-inducing factor; Interleukin-1 gamma; Interleukin-18
Gene Aliases: IGIF; IL-18; IL18
UniProt ID: (Pig) O19073
Entrez Gene ID: (Pig) 397057