This Antibody was verified by Neutralization to ensure that the antibody binds to the antigen stated. View Details
In direct ELISAs, approximately 50% cross-reactivity with recombinant canine IL-18, approximately 30% cross-reactivity with recombinant porcine IL-18, approximately 20% cross-reactivity with recombinant human IL-18 and recombinant rat IL-18, and less than 10% cross-reactivity with recombinant mouse IL-18 and recombinant rhesus macaque IL-18 is observed.
Reconstitute at 0.2 mg/mL in sterile PBS.
Endoxin level is <0.10 EU per 1 µg of the antibody by the LAL method.
The protein encoded by this gene is a proinflammatory cytokine. This cytokine can induce the IFN-gamma production of T cells. The combination of this cytokine and IL12 has been shown to inhibit IL4 dependent IgE and IgG1 production, and enhance IgG2a production of B cells. IL-18 binding protein can specifically interact with this cytokine, and thus negatively regulate its biological activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: IFN-gamma-inducing factor; IGIF; IL-1 gamma; IL-18; IL-1g; IL18; IL1F4; interferon gamma inducing factor; Interferon gamma-inducing factor; interferon-gamma-inducing factor; Interleukin-1 gamma; Interleukin-18
Gene Aliases: IGIF; IL18
UniProt ID: (Cat) Q95M33
Entrez Gene ID: (Cat) 493688