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Invitrogen
IL-18 Polyclonal Antibody
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Product Details
PA5-76082
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant full length Human IL-18.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Target Information
The protein encoded by this gene is a proinflammatory cytokine. This cytokine can induce the IFN-gamma production of T cells. The combination of this cytokine and IL12 has been shown to inhibit IL4 dependent IgE and IgG1 production, and enhance IgG2a production of B cells. IL-18 binding protein can specifically interact with this cytokine, and thus negatively regulate its biological activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: cytokine; Iboctadekin; IFN-gamma-inducing factor; il 18; IL-1 gamma; IL-18; IL18; ILN; Interferon gamma-inducing factor; interferon-gamma-inducing factor; Interleukin; interleukin 18 (interferon-gamma-inducing factor); Interleukin-1 gamma; Interleukin-18; Interleukin18; MGC12320
Gene Aliases: IGIF; IL-18; IL-1g; IL18; IL1F4
UniProt ID: (Human) Q14116, (Mouse) P70380, (Rat) P97636
Entrez Gene ID: (Human) 3606, (Mouse) 16173, (Rat) 29197
angiogenesis
inflammatory response
immune response
cell surface receptor signaling pathway
cell-cell signaling
cell proliferation
positive regulation of gene expression
positive regulation of macrophage derived foam cell differentiation
cytokine-mediated signaling pathway
natural killer cell activation
regulation of cell adhesion
sleep
positive regulation of chemokine production
positive regulation of granulocyte macrophage colony-stimulating factor production
positive regulation of interferon-gamma production
positive regulation of interleukin-13 production
positive regulation of interleukin-17 production
positive regulation of natural killer cell proliferation
positive regulation of tissue remodeling
interleukin-18-mediated signaling pathway
T-helper 1 type immune response
type 2 immune response
positive regulation of activated T cell proliferation
neutrophil activation
natural killer cell mediated cytotoxicity
positive regulation of tyrosine phosphorylation of STAT protein
cholesterol homeostasis
positive regulation of T-helper 2 cell differentiation
negative regulation of myoblast differentiation
positive regulation of transcription from RNA polymerase II promoter
positive regulation of smooth muscle cell proliferation
positive regulation of inflammatory response
defense response to Gram-positive bacterium
positive regulation of NF-kappaB transcription factor activity
positive regulation of NK T cell proliferation
positive regulation of protein kinase B signaling
establishment of skin barrier
triglyceride homeostasis
cellular response to lipopolysaccharide
positive regulation of cold-induced thermogenesis
positive regulation of neuroinflammatory response
positive regulation of NIK/NF-kappaB signaling
positive regulation of T-helper 1 cell cytokine production
MAPK cascade
response to hypoxia
extrinsic apoptotic signaling pathway via death domain receptors
positive regulation of smooth muscle cell migration
lipopolysaccharide-mediated signaling pathway
positive regulation of interleukin-8 production
positive regulation of tumor necrosis factor production
positive regulation of superoxide anion generation
positive regulation of collagen biosynthetic process
negative regulation of neutrophil apoptotic process
interferon-gamma biosynthetic process
interleukin-13 biosynthetic process
positive regulation of NF-kappaB import into nucleus
positive regulation of tyrosine phosphorylation of Stat3 protein
positive regulation of apoptotic process
positive regulation of vascular permeability
positive regulation of neuron apoptotic process
negative regulation of peptidyl-tyrosine phosphorylation
detection of mechanical stimulus involved in sensory perception of pain
cellular response to peptide hormone stimulus
cellular response to organic cyclic compound
positive regulation of male germ cell proliferation
positive regulation of blood vessel remodeling
osteoblast differentiation
learning or memory
response to radiation
response to cold
lung development
positive regulation of interleukin-1 beta production
response to peptide hormone
regulation of circadian sleep/wake cycle, non-REM sleep
digestive tract morphogenesis
response to hyperoxia
cellular response to hydrogen peroxide
cellular response to mechanical stimulus
cellular response to cAMP
cellular response to interferon-gamma
cellular response to tumor necrosis factor
cellular response to parathyroid hormone stimulus
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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