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Invitrogen
IL-19 Polyclonal Antibody
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FIGURE: 1 / 2
IL-19 Antibody (PA5-46903) in Neu
Neutralization of IL-19 in BaF3 mouse pro‚B cell line co-transfected with human IL‚20 Rα and IL‚20 Rβ. Samples were incubated in IL-19 polyclonal antibody (Product # PA5-46903). Recombinant Human IL‚19 stimulates proliferation in the BaF3 mouse pro‚B cell line co-transfected with human IL‚20 Rα and IL‚20 Rβ in a dose‚dependent manner (orange line). Proliferation elicited by Recombinant Human IL‚19 (3 ng/mL) is neutralized (green line) by increasing concentrations of Goat Anti-Human IL‚19 Antigen Affinity-purified Polyclonal Antibody. The N... View More
Product Details
PA5-46903
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Mouse
Host/Isotype
Goat
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
E. coli-derived recombinant human IL-19 Leu25-Ala177 (Phe175Ser)
Conjugate
Form
Lyophilized
Concentration
0.2 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS with 5% trehalose
Contains
No Preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Reconstitute at 0.2 mg/mL in sterile PBS.
Endoxin level is <0.10 EU per 1 µg of the antibody by the LAL method.
Target Information
The protein encoded by this gene is a cytokine that belongs to the IL10 cytokine subfamily. This cytokine is found to be preferentially expressed in monocytes. It can bind the IL20 receptor complex and lead to the activation of the signal transducer and activator of transcription 3 (STAT3). A similar cytokine in mouse is reported to up-regulate the expression of IL6 and TNF-alpha and induce apoptosis, which suggests a role of this cytokine in inflammatory responses. Alternatively spliced transcript variants encoding the distinct isoforms have been described.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: cytokine; il 19; IL-19; ILN; Interleukin; Interleukin-19; Interleukin19; MDA-1; melanoma differentiation associated protein-like protein; Melanoma differentiation-associated protein-like protein; NG.1; ZMDA1
Gene Aliases: IL-10C; IL19; MDA1; NG.1; ZMDA1
UniProt ID: (Human) Q9UHD0
Entrez Gene ID: (Human) 29949
apoptotic process
immune response
signal transduction
negative regulation of low-density lipoprotein particle clearance
reactive oxygen species metabolic process
positive regulation of apoptotic signaling pathway
negative regulation of extrinsic apoptotic signaling pathway
positive regulation of intrinsic apoptotic signaling pathway
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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