|Immunocytochemistry (ICC)||5 µg/ml|
|Western Blot (WB)||0.5 µg/ml|
|Western Blot (WB)||See 1 publications below|
|Tested Species reactivity||Human|
|Published species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||A peptide corresponding to amino acids near the carboxy terminus of IL-1RAcP|
|Purification||Antigen affinity chromatography|
|Contains||0.02% sodium azide|
|Storage conditions||Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C|
In Western blot applications, this antibody detects a band at ~66kDa. A suggested positive control is Hela cell lysate.
PA5-19921 can be used with blocking peptide PEP-0047.
The pro-inflammatory cytokine IL-1 induced cellular response requires two subunits of its receptor, IL-1 receptor I(IL-1RI) and IL-1 receptor accessory protein (IL-1RAcP). IL-1 RAcP forms a complex with IL-1RI in response to IL-1 treatment. The IL-1 receptor-associated kinase (IRAK), which mediates activation of NF-kappa-B inducing kinae (NIK) and of NF-kappa-B, recruites to the IL-1R complex through IL-1 RAcP. IL-1 activation of stress-activated protein kinase and of acid sphingomyelinase also requires IL-1RAcP. Like IL-1RI, IL-1RAcP subunit is essential for IL-1 mediated cellular response. IL-1RAcP is expressed in many tissues.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: C3orf13, IL-1RAcP, IL1R3; IL-1 receptor accessory protein; IL-1R-3; IL-1R3; Interleukin-1 receptor 3; Interleukin-1 receptor accessory protein; interleukin-1 receptor accessory protein beta
Gene Aliases: C3orf13; IL-1RAcP; IL1R3; IL1RAP
UniProt ID: (Human) Q9NPH3
Entrez Gene ID: (Human) 3556
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