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Proteintech
IL-23R Polyclonal Antibody
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Product Details
31798-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein
Conjugate
Form
Liquid
Concentration
550 µg/mL
Amount
82.5 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
Product Specific Information
Sequence of this protein is as follows: GITNINCSGH IWVEPATIFK MGMNISIYCQ AAIKNCQPRK LHFYKNGIKE RFQITRINKT TARLWYKNFL EPHASMYCTA ECPKHFQETL ICGKDISSGY PPDIPDEVTC VIYEYSGNMT CTWNAGKLTY IDTKYVVHVK SLETEEEQQY LTSSYINIST DSLQGGKKYL VWVQAANALG MEESKQLQIH LDDIVIPSAA VISRAETINA TVPKTIIYWD SQTTIEKVSC EMRYKATTNQ TWNVKEFDTN FTYVQQSEFY LEPNIKYVFQ VRCQETGKRY WQPWSSLFFH KTPETVPQVT SKAFQHDTWN SGLTVASIST GHLTSDNRGD IG
Target Information
IL-23R is a 629 aa, novel subunit of the receptor for cytokine IL23A/IL23 which pairs with the receptor molecule IL12RB1/IL12R beta 1and thus take part in IL23A signaling. Signal transduction analysis confirms that this protein associates constitutively with Janus kinase 2 (JAK2), and also binds to transcription activator STAT3 in a ligand-dependent manner. Alternative splicing results in six spliced isoforms of IL-23R. Reports suggest that IL-23R plays an important role in psoriasis pathogenesis and is also a potential therapeutic target in inflammatory bowel disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: hemopoietic cytokine receptor; IBD17; IL 23R; IL-23 receptor; IL-23R endodomain protein; IL-23R3-F3; IL-23R soluble receptor; IL-23R2-F1; IL-23R soluble receptor; IL-23R3-F1; IL-23R soluble receptor; IL-23R4; IL-23R truncated endodomain protein; IL-23R2-F2; Interleukin-23 receptor; type I cytokine receptor; IL-23R1
Gene Aliases: IL23R; PSORS7
UniProt ID: (Human) Q5VWK5
Entrez Gene ID: (Human) 149233
positive regulation of T cell mediated cytotoxicity
positive regulation of defense response to virus by host
immune system process
positive regulation of T-helper 1 type immune response
inflammatory response
JAK-STAT cascade
positive regulation of cell proliferation
cytokine-mediated signaling pathway
response to lipopolysaccharide
negative regulation of interleukin-10 production
positive regulation of granulocyte macrophage colony-stimulating factor production
positive regulation of interferon-gamma production
positive regulation of interleukin-12 production
positive regulation of interleukin-17 production
positive regulation of natural killer cell proliferation
response to interferon-gamma
interleukin-23-mediated signaling pathway
prolactin signaling pathway
positive regulation of T cell proliferation
positive regulation of activated T cell proliferation
positive regulation of memory T cell differentiation
innate immune response
positive regulation of osteoclast differentiation
defense response to Gram-negative bacterium
positive regulation of NK T cell activation
receptor signaling pathway via STAT
positive regulation of T-helper 17 type immune response
positive regulation of T-helper 17 cell lineage commitment
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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