Intact IgG appears on a non-reducing gel as ~150 kDa band and upon reduction generating a ~25 kDa light chain band and a ~50 kDa heavy chain.
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
Interleukin 31, or IL-31 is a cytokine secreted by differentiated CD4+ T helper type 2 (Th2) cells. It is also released during inflammation of the skin, by macrophages and T cells. Because IL-31 is secreted by activated Th2 cells, it has a role in host defense against infection and may be involved in asthma, allergy and different types of bowel diseases.
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