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|Tested species reactivity||Rat|
|Published species reactivity||Rat|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Recombinant rat IL-6.|
|Storage buffer||PBS, pH 7.3|
|Tested Applications||Dilution *|
|ELISA (ELISA)||Assay Dependent|
|Western Blot (WB)||Assay Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
Interleukin 6 is a cytokine secreted by T cells and macrophages, has shown to exhibit activity in response to tissue damage and infection. They have also been found to be involved in various other activities like development of blood, cancer, embryonic development, and regulation of the immune system. IL6 is included in a family of other cytokines which include ciliary neurotrophic factor, cardiotrophin-1, leukemia inhibitory factor and interleukin 11. IL-6 can bring about differentiation through a receptor system which requires a specific receptor and a signaling subunit, gp130.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Polysaccharide peptide from Coriolus versicolor induces interleukin 6-related extension of endotoxin fever in rats.
ARC0062 was used in blocking or activating experiment to assess the effect of polysaccharide peptide from Coriolus versicolor mushroom on the course of LPS-induced fever
|Jedrzejewski T,Piotrowski J,Kowalczewska M,Wrotek S,Kozak W||International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group (31:626)||2015|
Tempol treatment reduces anxiety-like behaviors induced by multiple anxiogenic drugs in rats.
ARC0062 was used in western blot to test if the effects of anxiogenic drugs can be mitigated using agents that minimize oxidative stress
|Patki G,Salvi A,Liu H,Atrooz F,Alkadhi I,Kelly M,Salim S||PloS one (10:null)||2015|
|Rat||Not Cited||Increased expression of interleukin-6 family members and receptors in urinary bladder with cyclophosphamide-induced bladder inflammation in female rats.||Girard BM,Cheppudira BP,Malley SE,Schutz KC,May V,Vizzard MA||Frontiers in neuroscience (5:null)||2011|
Novel mechanistic insights into treadmill exercise based rescue of social defeat-induced anxiety-like behavior and memory impairment in rats.
ARC0062 was used in western blot to study the epigenetic effects of physical exercise in social defeat-induced anxiety, depression, and memory impairment
|Patki G,Solanki N,Atrooz F,Ansari A,Allam F,Jannise B,Maturi J,Salim S||Physiology & behavior (130:135)||2014|
|Rat||Not Cited||Super CitriMax (HCA-SX) attenuates increases in oxidative stress, inflammation, insulin resistance, and body weight in developing obese Zucker rats.||Asghar M,Monjok E,Kouamou G,Ohia SE,Bagchi D,Lokhandwala MF||Molecular and cellular biochemistry (304:93)||2007|
BSF2; HGF; IFNB2; IL-6; Interleukin 6 (interferon, beta 2); interleukin HP-1; interleukin-6
Ifnb2; Il-6; Il6; ILg6