|Tested species reactivity||Mouse|
|Published species reactivity||Mouse, Not Applicable|
|Host / Isotype||Rat / IgG1, kappa|
|Immunogen||Recombinant mouse IL-6.|
|Storage buffer||PBS, pH 7.2|
|Tested Applications||Dilution *|
|ELISA (ELISA)||Assay Dependent|
|Flow Cytometry (Flow)||Assay Dependent|
|Immunohistochemistry (IHC)||Assay Dependent|
|Neutralization (Neu)||Assay Dependent|
|Western Blot (WB)||Assay Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
Interleukin 6 is a cytokine secreted by T cells and macrophages, has shown to exhibit activity in response to tissue damage and infection. They have also been found to be involved in various other activities like development of blood, cancer, embryonic development, and regulation of the immune system. IL6 is included in a family of other cytokines which include ciliary neurotrophic factor, cardiotrophin-1, leukemia inhibitory factor and interleukin 11. IL-6 can bring about differentiation through a receptor system which requires a specific receptor and a signaling subunit, gp130.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
|Not Applicable||Not Cited||
Deficiency of heme oxygenase-1 impairs renal hemodynamics and exaggerates systemic inflammatory responses to renal ischemia.
AMC0862 was used in blocking or activating experiment to assess the sensitivity of heme oxygenase-1 knockout mice to renal ischemia
|Tracz MJ,Juncos JP,Croatt AJ,Ackerman AW,Grande JP,Knutson KL,Kane GC,Terzic A,Griffin MD,Nath KA||Kidney international (72:1073)||2007|
|Mouse||Not Cited||Linkage of IL-6 with neutrophil chemoattractant expression in virus-induced ocular inflammation.||Fenton RR,Molesworth-Kenyon S,Oakes JE,Lausch RN||Investigative ophthalmology and visual science (43:737)||2002|
Enhancement of antigen-presenting cell surface molecules involved in cognate interactions by immunostimulatory DNA sequences.
AMC0862 was used in blocking assay to demonstrate that immunostimulatory DNA up-regulates a distinct profile of cell surface molecules on macrophages and B cells in vitro and in vivo.
|Martin-Orozco E,Kobayashi H,Van Uden J,Nguyen MD,Kornbluth RS,Raz E||International immunology (11:1111)||1999|