Peptide sequence: LTSSFESAAY PGWFLCTVPE ADQPVRLTQL PENGGWNAPI TDFYFQQCD
Sequence homology: Dog: 79%; Guinea Pig: 100%; Horse: 79%; Human: 100%; Mouse: 86%; Rabbit: 79%; Rat: 83%; Yeast: 90%
The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine was shown to specifically inhibit the activation of NF-kappaB induced by interleukin 1 family, member 6 (IL1F6). This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. Two alternatively spliced transcript variants encoding the same protein have been reported.
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Protein Aliases: FIL1 delta; IL-1 delta; IL-1 related protein 3; IL-1-related protein 3; IL-1F5; IL-1F5 (IL-1HY1, FIL1-delta, IL-1RP3, IL-1L1, IL-1-delta); IL-1HY1; IL-1L1; IL-1ra homolog 1; IL-1RP3; IL-36Ra; IL1F5 (Canonical product IL-1F5a); interleukin 1 family, member 5 (delta); Interleukin-1 delta; Interleukin-1 family member 5; Interleukin-1 HY1; Interleukin-1 receptor antagonist homolog 1; Interleukin-1-like protein 1; Interleukin-36 receptor antagonist protein; MGC29840
Gene Aliases: FIL1; FIL1(DELTA); FIL1D; IL-36Ra; IL1F5; IL1HY1; IL1L1; IL1RP3; IL36RA; IL36RN; PSORP; PSORS14; UNQ1896/PRO4342
UniProt ID: (Human) Q9UBH0
Entrez Gene ID: (Human) 26525
Molecular Function: interleukin superfamily