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Proteintech
IL2RG Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
11409-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
IL2RG Fusion Protein Ag1911 (1-369 aa encoded by BC014972)
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.14 mg/mL
Amount
21 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MLKPSLPFT SLLFLQLPLL GVGLNTTILT PNGNEDTTAD FFLTTMPTDS LSVSTLPLPE VQCFVFNVEY MNCTWNSSSE PQPTNLTLHY WYKNSDNDKV QKCSHYLFSE EITSGCQLQK KEIHLYQTFV VQLQDPREPR RQATQMLKLQ NLVIPWAPEN LTLHKLSESQ LELNWNNRFL NHCLEHLVQY RTDWDHSWTE QSVDYRHKFS LPSVDGQKRY TFRVRSRFNP LCGSAQHWSE WSHPIHWGSN TSKENPFLFA LEAVVISVGS MGLIISLLCV YFWLERTMPR IPTLKNLEDL VTEYHGNFSA WSGVSKGLAE SLQPDYSERL CLVSEIPPKG GALGEGPGAS PCNQHSPYWA PPCYTLKPET (1-369 aa encoded by BC014972)
Target Information
IL2RG is an important signaling component of many interleukin receptors, including those of interleukin -2, -4, -7 and -21, and is thus referred to as the common gamma chain. Mutations in this gene cause X-linked severe combined immunodeficiency (XSCID), as well as X-linked combined immunodeficiency (XCID), a less severe immunodeficiency disorder.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CD132 antigen; common cytokine receptor gamma chain; common gamma chain; gamma C receptor; gammaC; IL-2 receptor subunit gamma; IL-2R subunit gamma; IL2R gamma; interleukin 2 receptor, gamma; interleukin 2 receptor, gamma (severe combined immunodeficiency); interleukin-2 receptor subunit gamma; nonfunctional common cytokine receptor gamma chain; unnamed protein product
Gene Aliases: [g]c; Ab2-183; CD132; CIDX; gamma(c); gc; IL-2RG; IMD4; P64; SCIDX; SCIDX1
UniProt ID: (Human) P31785, (Mouse) P34902
Entrez Gene ID: (Human) 3561, (Rat) 140924, (Mouse) 16186
JAK-STAT cascade
regulation of gene expression
positive regulation of gene expression
cellular homeostasis
positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation
positive regulation of T cell differentiation in thymus
interleukin-15-mediated signaling pathway
interleukin-2-mediated signaling pathway
interleukin-7-mediated signaling pathway
interleukin-9-mediated signaling pathway
positive regulation of B cell differentiation
positive regulation of lymphocyte differentiation
positive regulation of phagocytosis
leukocyte homeostasis
immune response
signal transduction
immunoglobulin mediated immune response
cytokine-mediated signaling pathway
lymphocyte differentiation
natural killer cell activation
interleukin-4-mediated signaling pathway
positive regulation of tyrosine phosphorylation of STAT protein
negative regulation of tyrosine phosphorylation of STAT protein
negative regulation of apoptotic process
positive regulation of MAPK cascade
positive regulation of T cell differentiation
positive regulation of leukocyte proliferation
negative regulation of Fas signaling pathway
positive regulation of leukocyte differentiation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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