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IMP4/SPPL2B Polyclonal Antibody
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Product Details
BS-11682R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human SPPL2B, amino acids 55-135.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
SPPL2B is a member of the GXGD family of aspartic proteases. The GXGD proteases are transmembrane proteins with two conserved catalytic motifs localized within the membrane-spanning regions. This enzyme localizes to endosomes, lysosomes, and the plasma membrane. It cleaves the transmembrane domain of tumor necrosis factor alpha to release the intracellular domain, which triggers cytokine expression in the innate and adaptive immunity pathways.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: IMP-4; IMPAS; Intramembrane protease 4; MGC111084; Presenilin homologous protein 4; Presenilin-like protein 1; protein SPP-like 2B; protein SPPL2b; PSH4; Signal peptide peptidase-like 2B; SPP-like 2B
Gene Aliases: 3110056O03Rik; AW550292; IMP-4; IMP4; KIAA1532; PSH4; PSL1; RGD1308556; SPPL2B
UniProt ID: (Human) Q8TCT7, (Rat) Q5PQL3, (Mouse) Q3TD49
Entrez Gene ID: (Human) 56928, (Rat) 362828, (Mouse) 73218
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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