Search
Invitrogen
INHBB Polyclonal Antibody
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Additional Information:
{{banner.description}}
Product Details
PA5-50818
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide of human inhibin, beta B
Conjugate
Form
Liquid
Concentration
2.9 mg/mL
Amount
290 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 40% glycerol
Contains
0.05% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
The antibody detects endogenous levels of total INHBB protein.
Target Information
The inhibin beta B subunit joins the alpha subunit to form a pituitary FSH secretion inhibitor. Inhibin has been shown to regulate gonadal stromal cell proliferation negatively and to have tumour-suppressor activity. In addition, serum levels of inhibin have been shown to reflect the size of granulosa-cell tumors and can therefore be used as a marker for primary as well as recurrent disease. Because expression in gonadal and various extragonadal tissues may vary severalfold in a tissue-specific fashion, it is proposed that inhibin may be both a growth/differentiation factor and a hormone. Furthermore, the beta B subunit forms a homodimer, activin B, and also joins with the beta A subunit to form a heterodimer, activin AB, both of which stimulate FSH secretion.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: activin AB beta polypeptide; Activin beta-B chain; activin betaB; beta-B inhibin propeptide; Inhibin beta B chain; inhibin beta B subunit; inhibin beta subunit B; inhibin beta-B-subunit precursor; Inhibin, beta-2
Gene Aliases: INHBB
UniProt ID: (Human) P09529, (Mouse) Q04999, (Rat) P17491
Entrez Gene ID: (Human) 3625, (Mouse) 16324, (Rat) 25196
ovarian follicle development
defense response
transmembrane receptor protein serine/threonine kinase signaling pathway
spermatogenesis
male gonad development
female gonad development
cellular response to starvation
response to wounding
response to insecticide
pituitary gland development
cell differentiation
negative regulation of hepatocyte growth factor production
cellular response to insulin stimulus
activin receptor signaling pathway
response to gonadotropin
cellular response to leptin stimulus
adhesion of symbiont to host cell
fat cell differentiation
negative regulation of insulin secretion
positive regulation of follicle-stimulating hormone secretion
negative regulation of follicle-stimulating hormone secretion
oocyte development
positive regulation of ovulation
cellular response to calcium ion
cellular response to cAMP
cellular response to interleukin-1
cellular response to cholesterol
seminiferous tubule development
cellular response to thyroid hormone stimulus
apoptotic signaling pathway
cellular response to Thyroglobulin triiodothyronine
cellular response to phorbol 13-acetate 12-myristate
positive regulation of apoptotic signaling pathway
eye development
response to mechanical stimulus
positive regulation of pathway-restricted SMAD protein phosphorylation
growth
regulation of MAPK cascade
negative regulation of hepatocyte growth factor biosynthetic process
SMAD protein signal transduction
response to organic cyclic compound
regulation of apoptotic process
cell development
cellular response to organic cyclic compound
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support