Immunogen sequence: SRLLGLVRYR LEHGGQEHAL FLYTHRRMAI TGDDVSLDQI VPVSRDFTLE EVSPDGELYI LGSDVTV
Cellular calcium signaling is controlled by the production of inositol phosphates (IPs) by phospholipase C in response to extracellular signals. The IP signaling molecules are inactivated by a family of inositol polyphosphate-5-phosphatases (5-phosphatases). INPP5B encodes the type II 5-phosphatase. The protein is localized to the cytosol and mitochondria, and associates with membranes through an isoprenyl modification near the C-terminus. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: 5PTase; 75 kDa inositol polyphosphate-5-phosphatase; inositol polyphosphate-5-phosphatase, 75kDa; Phosphoinositide 5-phosphatase; Type II inositol 1,4,5-trisphosphate 5-phosphatase
Gene Aliases: 5PTase; INPP5B; OCRL2
UniProt ID: (Human) P32019
Entrez Gene ID: (Human) 3633