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Product Details
21417-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
INPP5J Fusion Protein Ag15996 (777-1006 aa encoded by BC109288)
Conjugate
Form
Liquid
Concentration
0.17 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: RVGFRHCKD YVAYVRAKHE DVDGNTYQVT FSEESLPKGH GDFILGYYSH NHSILIGITE PFQISLPSSE LASSSTDSSG TSSEGEDDST LELLAPKSRS PSPGKSKRHR SRSPGLARFP GLALRPSSRE RRGASRSPSP QSRRLSRVAP DRSSNGSSRG SSEEGPSGLP GPWAFPPAVP RSLGLLPALR LETVDPGGGG SWGPDREALA PNSLSPSPQG HRGLEEGGLG P (777-1006 aa encoded by BC109288)
Target Information
Inositol and phosphatidylinositol phosphates are important for numerous cellular processes, including neuronal survival and signal transductions from growth factors, neurotransmitters and G protein coupled receptors. INPP5J (inositol polyphosphate-5-phosphatase J), also known as phosphatidylinositol 4,5-bisphosphate 5-phosphatase A, PIPP (proline-rich inositol polyphosphate 5-phosphatase), PIB5PA or INPP5, is a 1,006 amino acid cytoplasmic protein that assists in the conversion of inositol 1,4-bisphosphate from inositol 1,4,5-trisphosphate. Expressed in lung, stomach, kidney, brain, small intestine and heart, INPP5J localizes to membrane ruffles, where it may also participate in modulating inositol and phosphatidylinositol polyphosphate-binding proteins. Encoded by a gene located on human chromosome 22, INPP5J undergoes alternative splicing to produce three isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Inositol polyphosphate 5-phosphatase J; phosphatidylinositol (4,5) bisphosphate 5-phosphatase, A; Phosphatidylinositol 1,3,4,5-tetrakisphosphate 5-phosphatase; Phosphatidylinositol 1,4,5-trisphosphate 5-phosphatase; Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A; Proline-rich inositol polyphosphate 5-phosphatase
Gene Aliases: Inpp; INPP5; INPP5J; PIB5PA; PIPP
UniProt ID: (Human) Q15735, (Mouse) P59644, (Rat) Q9JMC1
Entrez Gene ID: (Human) 27124, (Mouse) 170835, (Rat) 171088
phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity
inositol-polyphosphate 5-phosphatase activity
protein binding
SH3 domain binding
phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity
inositol-1,4,5-trisphosphate 5-phosphatase activity
inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity
hydrolase activity
phosphatase
Performance Guarantee
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