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Invitrogen
INTU Polyclonal Antibody
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Product Details
PA5-57785
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human INTU. Recombinant protein control fragment (Product #RP-103774).
Conjugate
Form
Liquid
Concentration
0.05 mg/mL
Amount
5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: NDNGPVSILK HQSNQKTGVI VQQRYKDVNV YVNPKKLTVI KAKEQLKLLE VLVGIIHQTK WSWRRTGKQG DGERLVVHGL LPGGSAMKSG QVLIGDV
Highest antigen sequence identity to the following orthologs: Mouse - 84%, Rat - 82%.
Target Information
Plays a key role in ciliogenesis and embryonic development. Regulator of cilia formation by controlling the organization of the apical actin cytoskeleton and the positioning of the basal bodies at the apical cell surface, which in turn is essential for the normal orientation of elongating ciliary microtubules. Plays a key role in definition of cell polarity via its role in ciliogenesis but not via conversion extension. Has an indirect effect on hedgehog signaling. Proposed to function as core component of the CPLANE (ciliogenesis and planar polarity effectors) complex involved in the recruitment of peripheral IFT-A proteins to basal bodies (PubMed:27158779). [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ciliogenesis and planar polarity effector 4; ciliogenesis and planar polarity effector complex subunit 4; Inturned planar cell polarity effector homolog; PDZ domain containing 6; PDZ domain-containing protein 6; Protein inturned; unnamed protein product
Gene Aliases: CPLANE4; INT; INTU; KIAA1284; OFD17; PDZD6; PDZK6; SRTD20
UniProt ID: (Human) Q9ULD6
Entrez Gene ID: (Human) 27152
establishment of planar polarity
smoothened signaling pathway
nervous system development
regulation of smoothened signaling pathway
negative regulation of keratinocyte proliferation
vesicle-mediated transport
spinal cord dorsal/ventral patterning
neural tube development
cell projection organization
keratinocyte differentiation
regulation of ossification
hair follicle morphogenesis
protein localization to organelle
intraciliary transport
embryonic digit morphogenesis
tongue morphogenesis
motile cilium assembly
positive regulation of smoothened signaling pathway
cell division
negative regulation of cell division
palate development
limb development
cilium morphogenesis
regulation of cilium assembly
non-motile cilium assembly
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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