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Bethyl Laboratories
IP3R3 Polyclonal Antibody
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FIGURE: 1 / 2
IP3R3 Antibody (IHC-00639) in IHC (P)
Detection of human IP3R3 by immunohistochemistry. Sample: FFPE section of human stomach carcinoma. Antibody: Affinity purified rabbit anti-IP3R3 (Product # IHC-00639) used at a dilution of 1:100. Detection: Red-fluorescent goat anti-rabbit IgG-heavy and light chain cross-adsorbed Antibody DyLight® 594 Conjugated used at a dilution of 1:100.
Product Details
IHC-00639
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Region between residue 625 and 675 of human inositol 1, 4,5-triphosphate receptor, type 3.
Conjugate
Form
Liquid
Concentration
0.25 mg/mL
Amount
25 µg
Purification
Antigen affinity chromatography
Storage buffer
TBS, pH 7.0 to 8.0, with 0.1% BSA
Contains
0.09% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Based on 100% sequence identity, this antibody is predicted to react with Guinea pig_10141, Orangutan, Gorilla and Northern white-cheeked gibbon
Target Information
This gene encodes a receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. The receptor contains a calcium channel at the C-terminus and the ligand-binding site at the N-terminus. Knockout studies in mice suggest that type 2 and type 3 inositol 1,4,5-trisphosphate receptors play a key role in exocrine secretion underlying energy metabolism and growth.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: inositol 1,4,5-triphosphate receptor, type 3; Inositol 1,4,5-trisphosphate-gated calcium channel ITPR3; insP3R3; IP3 receptor; IP3 receptor isoform 3; IP3R-3; Type 3 inositol 1,4,5-trisphosphate receptor; Type 3 InsP3 receptor
Gene Aliases: CMT1J; IP3R; IP3R-3; IP3R3; ITPR3
UniProt ID: (Human) Q14573
Entrez Gene ID: (Human) 3710
inositol hexakisphosphate binding
ion channel activity
inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
calcium channel activity
calcium ion binding
protein binding
ATP binding
zinc ion binding
calcium-release channel activity
phosphatidylinositol binding
inositol 1,3,4,5 tetrakisphosphate binding
inositol 1,4,5 trisphosphate binding
ion transport
calcium ion transport
G-protein coupled receptor signaling pathway
positive regulation of cytosolic calcium ion concentration
memory
calcium-mediated signaling
platelet activation
ion transmembrane transport
sensory perception of taste
sensory perception of bitter taste
sensory perception of sweet taste
sensory perception of umami taste
release of sequestered calcium ion into cytosol
protein homotetramerization
response to calcium ion
calcium ion homeostasis
transmembrane transport
long-term synaptic potentiation
calcium ion transmembrane transport
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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