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Proteintech
IPO8 Polyclonal Antibody
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Product Details
32476-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
IPO8 fusion protein Ag35395
Conjugate
Form
Liquid
Concentration
400 µg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
Product Specific Information
Sequence of this protein is as follows: LGLKQVCATR QLVNREDRSK AEKADMEENE EISSDEEETN VTAQAMQSNN GRGEDEEEED DDWDEEVLEE TALEGFSTPL DLDNSVDEYQ FFTQALITVQ SRDAAWYQLL MAPLSEDQRT ALQEVYTLAE HRRTVAEAKK KIEQQGGFTF ENKGVLSAFN FGTVPSNN
Target Information
Importin 8 is a 1037 amino acid nuclear protein with a RAN binding site. It belongs to RAN-binding protein super family and hence shares an N-terminal sequence motif with importin-beta that appears to account for RAN GTP binding. It binds to the nuclear pore complex (NPC) and is well known as a transport carrier that mediates nuclear import of ribosomal proteins with a classical nuclear localization signal. Importin 8 works by binding to the nuclear pore complex and, along with RANGTP and RANBP1, inhibits the GAP stimulation of the RAN GTPase. Along with transportin it also helps in the nuclear import of SRP19.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ATP-binding cassette, sub-family C (CFTR/MRP), member 10; FLJ26580; Imp8; Importin-8; oocyte maturation 1; RAN binding protein 8; Ran-binding protein 8; RanBP8
Gene Aliases: 6230418K12Rik; Abcc10; C130009K11Rik; IPO8; MRP7; OM-1; Om1; RANBP8
UniProt ID: (Human) O15397, (Mouse) Q7TMY7
Entrez Gene ID: (Human) 10526, (Mouse) 320727
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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