Invitrogen

IRAK-M Polyclonal Antibody

View all (20) IRAK-M antibodies

Questions & Answers

Questions & Answers

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IRAK-M Antibody in Immunohistochemistry (IHC) — Immunohistochemistry analysis of IRAK-M in human lung cancer tissue. Samples were incubated with IRAK-M polyclonal antibody (Product # PA5-95154).

IRAK-M Antibody in Immunohistochemistry (IHC) — Immunohistochemistry analysis of IRAK-M in mouse liver tissue. Samples were incubated with IRAK-M polyclonal antibody (Product # PA5-95154).

IRAK-M Antibody in Western Blot (WB) — Western blot analysis of IRAK-M in Lane 1: HeLa cell lysate, Lane 2: Jurkat cell lysate. Samples were incubated with IRAK-M polyclonal antibody (Product # PA5-95154).

Product Details

PA5-95154

Applications	Tested Dilution	Publications
Western Blot (WB)	0.1-0.5 µg/mL	-
Immunohistochemistry (Paraffin) (IHC (P))	0.5-1 µg/mL	-

Product Specifications
Species Reactivity	Human, Mouse, Rat
Host/Isotype	Rabbit / IgG
Class	Polyclonal
Type	Antibody
Immunogen	A synthetic peptide corresponding to a sequence at the C-terminus of mouse IRAKM, identical to the related rat sequence, and different from the related human sequence by one amino acid. View antigen
Conjugate	Unconjugated
Form	Lyophilized
Concentration	500 µg/mL
Purification	Affinity chromatography
Storage buffer	PBS with 5mg BSA
Contains	0.05mg sodium azide, 0.05mg thimerosal
Storage conditions	Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
RRID	AB_2806959

Product Specific Information

Synthetic peptide sequence: 349-364aa, KHLWYMPEEYIRQGRL.

Reconstitution information: Add 0.2 mL of distilled water will yield a concentration of 500 µg/mL.

Target Information

This gene encodes a member of the interleukin-1 receptor-associated kinase protein family. Members of this family are essential components of the Toll/IL-R immune signal transduction pathways. This protein is primarily expressed in monocytes and macrophages and functions as a negative regulator of Toll-like receptor signaling. Mutations in this gene are associated with a susceptibility to asthma. Alternate splicing results in multiple transcript variants.

⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: FLJ13601; IL-1 receptor-associated kinase M; Interleukin-1 receptor-associated kinase 3; IRAK-3; IRAK-M; IRAK3

Gene Aliases: 4833428C18Rik; AI563835; ASRT5; IRAK-M; IRAK3; IRAKM

UniProt ID: (Human) Q9Y616, (Mouse) Q8K4B2

Entrez Gene ID: (Human) 11213, (Mouse) 73914, (Rat) 314870

negative regulation of cytokine-mediated signaling pathway MyD88-dependent toll-like receptor signaling pathway protein phosphorylation response to virus positive regulation of macrophage tolerance induction negative regulation of macrophage cytokine production cytokine-mediated signaling pathway negative regulation of NF-kappaB transcription factor activity response to peptidoglycan response to lipopolysaccharide negative regulation of interleukin-12 production negative regulation of interleukin-6 production negative regulation of tumor necrosis factor production negative regulation of toll-like receptor signaling pathway negative regulation of protein catabolic process negative regulation of protein complex disassembly regulation of protein complex disassembly response to exogenous dsRNA negative regulation of MAP kinase activity negative regulation of innate immune response protein autophosphorylation positive regulation of NF-kappaB transcription factor activity interleukin-1-mediated signaling pathway response to interleukin-1 toll-like receptor signaling pathway apoptotic process signal transduction phosphorylation intracellular signal transduction regulation of apoptotic process biological_process

Process(es)

magnesium ion binding protein serine/threonine kinase activity ATP binding protein homodimerization activity protein heterodimerization activity nucleotide binding protein kinase activity protein binding kinase activity transferase activity transferase activity, transferring phosphorus-containing groups molecular_function