Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
Invitrogen
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It is not recommended to aliquot this antibody.
IL-1 receptor associated kinases (IRAKs) are serine/threonine kinases involved in signaling via Toll/IL-1 pathways. It is rapidly recruited by MYD88 to the receptor-signaling complex upon TLR activation. IRAK's association with MYD88 leads to IRAK1 phosphorylation by IRAK4 and subsequent autophosphorylation and kinase activation. Alternatively, IRAK1 can phosphorylate TIRAP to promote its ubiquitination and subsequent degradation. IRAK1 also phosphorylates the interferon regulatory factor 7 (IRF7) to induce its activation and translocation to the nucleus. This results in the transcriptional activiation of type I IFN genes, which drive the cell in an antiviral state.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Interleukin-1 receptor-associated kinase 1; IRAK-1; Pelle homolog
Gene Aliases: IRAK; IRAK1; pelle
UniProt ID: (Human) P51617
Entrez Gene ID: (Human) 3654
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