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Invitrogen

IRGM Polyclonal Antibody

View all (6) IRGM antibodies

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IRGM Polyclonal Antibody

Product Details

PA5150415

Applications
Tested Dilution
Publications

Western Blot (WB)

0.04-0.4 µg/mL
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant Protein Epitope Signature Tag (PrEST) antigen sequence.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.1 mg/mL

Amount

10 µg

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Highest antigen sequence identity to the following orthologs: Mouse- 52%, Rat- 55%.

Sequence of this protein is as follows: EAMNVEKASA DGNLPEVISN IKETLKIVSR TPVNITMAGD SGNGMSTFIS ALRNTGHEGK ASPPTELVKA TQRCASYFSS HFSNVVLWDL P

Target Information

Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components. Two of the strongest hits implicate genes IRGM and ATG16L1, which encode proteins thought to be critical to the autophagy pathway and being significantly associated with Crohn's disease. In mouse, IRGM belongs to a family of -gamma-interferon-induced GTP-binding proteins of approximately 48 kDa. Murine IRGM induces autophagy and generates large autolysosomal organelles as a mechanism for the elimination of intracellular Mycobacterium tuberculosis. Human IRGM is also involved in autophagy and plays a role in the control of intracellular pathogens and in the reduction of intracellular bacillary load.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Immunity-related GTPase family M protein; Immunity-related GTPase family M protein 1; immunity-related GTPase family, M1; Interferon-inducible protein 1; LPS-stimulated RAW 264.7 macrophage protein 47 homolog; LRG 47; LRG-47; LRG-47-like protein; MGC149263

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Gene Aliases: IBD19; IFI1; IRGM; IRGM1; LRG-47; LRG47

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UniProt ID: (Human) A1A4Y4

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Entrez Gene ID: (Human) 345611

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Function(s)
nucleotide binding GTPase activity obsolete small monomeric GTPase activity protein binding GTP binding hydrolase activity protein kinase binding protein binding, bridging protein serine/threonine kinase activator activity CARD domain binding BH3 domain binding cardiolipin binding
Process(es)
autophagosome assembly positive regulation of protein phosphorylation immune system process autophagy inflammatory response lysosome organization positive regulation of autophagy positive regulation of peptidyl-threonine phosphorylation protein catabolic process protein destabilization negative regulation of type I interferon production negative regulation of interferon-gamma production positive regulation of peptidyl-serine phosphorylation cellular response to interferon-beta defense response to bacterium positive regulation of macrophage activation negative regulation of I-kappaB kinase/NF-kappaB signaling regulation of protein complex assembly NLRP3 inflammasome complex assembly innate immune response negative regulation of innate immune response negative regulation of defense response to virus negative regulation of inflammatory response protein stabilization defense response to Gram-negative bacterium positive regulation of interferon-gamma-mediated signaling pathway regulation of protein complex stability protein lipidation involved in autophagosome assembly CAMKK-AMPK signaling cascade protein-containing complex assembly nucleotide-binding oligomerization domain containing 2 signaling pathway protein targeting to vacuole involved in autophagy cellular response to lipopolysaccharide positive regulation of protein serine/threonine kinase activity positive regulation of mitochondrial fission autophagosome maturation cellular response to virus antibacterial innate immune response negative regulation of cGAS/STING signaling pathway negative regulation of protein localization to nucleus positive regulation of protein localization to nucleus negative regulation of NLRP3 inflammasome complex assembly positive regulation of autophagosome maturation positive regulation of mitophagy positive regulation of xenophagy positive regulation of lysosome organization
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