PA5-27789 targets Islet 1 in WB applications and shows reactivity with Human samples.
The PA5-27789 immunogen is recombinant protein fragment corresponding to a region within amino acids 23 and 331 of Human Islet 1.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.
This gene encodes a member of the LIM/homeodomain family of transcription factors. The encoded protein binds to the enhancer region of the insulin gene, among others, and may play an important role in regulating insulin gene expression. The encoded protein is central to the development of pancreatic cell lineages and may also be required for motor neuron generation. Mutations in this gene have been associated with maturity-onset diabetes of the young.
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Protein Aliases: Insulin gene enhancer protein ISL-1; Isl-1; isl-1 homeobox; ISL1 transcription factor; ISL1 transcription factor LIM/homeodomain (islet-1); ISL1 transcription factor, LIM/homeodomain; ISL1 transcription factor, LIM/homeodomain 1; Islet-1; ISLET1; LIM/homeodomain
Gene Aliases: Isl-1; isl-1=homeobox; ISL1; ISLET1