Predicted to react with chicken, zebrafish and human based on sequence homology.
This gene encodes a member of the LIM/homeodomain family of transcription factors. The encoded protein binds to the enhancer region of the insulin gene, among others, and may play an important role in regulating insulin gene expression. The encoded protein is central to the development of pancreatic cell lineages and may also be required for motor neuron generation. Mutations in this gene have been associated with maturity-onset diabetes of the young.
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Protein Aliases: Insulin gene enhancer protein ISL-1; isl-1 homeobox; Isl1; ISL1 transcription factor LIM/homeodomain (islet-1); ISL1 transcription factor, LIM/homeodomain 1; Islet-1
Gene Aliases: Isl-1; isl-1=homeobox; Isl1
UniProt ID: (Rat) P61374
Entrez Gene ID: (Rat) 64444