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ITCH/AIP4 Polyclonal Antibody

View all (21) ITCH antibodies

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ITCH/AIP4 Polyclonal Antibody

Product Details

ITCH-101AP

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,000
-

Immunohistochemistry (IHC)

1:50-1:250
-

ELISA (ELISA)

1:10,000
-

Immunoprecipitation (IP)

1:50-1:250
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide taken within amino acid reigon 250-300 on human ITCH protein.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5-1.5 mg/mL

Purification

Affinity chromatography

Storage buffer

proprietary buffer, pH 7.4-7.8, with 30% glycerol, 0.5% BSA

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

Atrophin-1 contains a polyglutamine repeat, expansion of which is responsible for dentatorubral and pallidoluysian atrophy. The protein encoded by this gene interacts with atrophin-1. This encoded protein is a closely related member of the NEDD4-like protein family. This family of proteins are E3 ubiquitin-ligase molecules and regulate key trafficking decisions, including targeting of proteins to proteosomes or lysosomes. This encoded protein contains four tandem WW domains and a HECT domain. It can act as a transcriptional corepressor of p45/NFE2 and may participate in the regulation of immune responses by modifying Notch-mediated signaling. It is highly similar to the mouse Itch protein, which has been implicated in the regulation and differentiation of erythroid and lymphoid cells.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: atrophin-1 interacting protein 4; dJ468O1.1; HECT-type E3 ubiquitin transferase Itchy homolog; itch E3 ubiquitin ligase; Itchy; itchy E3 ubiquitin protein ligase homolog; Nedd 4 like ubiquitin protein ligase; NFE2-associated polypeptide 1; unnamed protein product

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Gene Aliases: 6720481N21Rik; 8030492O04Rik; A130065M08; ADMFD; AIF4; AIP4; C230047C07Rik; NAPP1

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UniProt ID: (Human) Q96J02, (Mouse) Q8C863

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Entrez Gene ID: (Human) 83737, (Rat) 311567, (Mouse) 16396

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Function(s)
ubiquitin-protein transferase activity protein binding ligase activity ubiquitin-like protein transferase activity ubiquitin-ubiquitin ligase activity ribonucleoprotein complex binding ubiquitin-like protein ligase binding CXCR chemokine receptor binding ubiquitin protein ligase activity arrestin family protein binding catalytic activity
Process(es)
protein polyubiquitination positive regulation of T cell anergy negative regulation of immune system process positive regulation of immune system process ubiquitin-dependent protein catabolic process protein monoubiquitination positive regulation of catabolic process protein ubiquitination receptor internalization protein K29-linked ubiquitination negative regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway negative regulation of apoptotic process negative regulation of I-kappaB kinase/NF-kappaB signaling proteasome-mediated ubiquitin-dependent protein catabolic process positive regulation of protein catabolic process negative regulation of JNK cascade negative regulation of alpha-beta T cell proliferation negative regulation of defense response to virus negative regulation of multicellular organismal process protein autoubiquitination protein K63-linked ubiquitination protein K48-linked ubiquitination regulation of protein deubiquitination protein branched polyubiquitination negative regulation of intracellular signal transduction positive regulation of receptor catabolic process regulation of cell growth inflammatory response negative regulation of type I interferon production nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway viral entry into host cell regulation of necroptotic process regulation of hematopoietic stem cell differentiation cytoplasmic pattern recognition receptor signaling pathway response to oxidative stress CXCL12-activated CXCR4 signaling pathway
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