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| Applications | Tested Dilution | Publications |
|---|---|---|
Western Blot (WB) |
1:500-1:1,000 | - |
Immunocytochemistry (ICC/IF) |
1:20-1:200 | - |
Flow Cytometry (Flow) |
0.2 µg/1x10^6 cells | - |
| Product Specifications | |
|---|---|
Species Reactivity |
Human |
Host/Isotype |
Mouse / IgG2a |
Class |
Monoclonal |
Type |
Antibody |
Clone |
2E8G11 |
Immunogen |
ITM2C Fusion Protein Ag4409 (1-230 aa encoded by BC025742) |
Conjugate |
Unconjugated
|
Form |
Liquid |
Concentration |
0.95 mg/mL |
Purification |
Caprylic acid precipitation |
Storage buffer |
PBS, pH 7.3, with 50% glycerol |
Contains |
0.1% sodium azide |
Storage conditions |
-20°C |
Immunogen sequence: MVKISFQPA VAGIKGDKAD KASASAPAPA SATEILLTPA REEQPPQHRS KRGSSVGGVC YLSMGMVVLL MGLVFASVYI YRYFFLAQLA RDNFFRCGVL YEDSLSSQVR TQMELEEDVK IYLDENYERI NVPVPQFGGG DPADIIHDFQ RRGTYLPQTY IIQEEMVVTE HVSDKEALGS FIYHLCNGKD TYRLRRRATR RRINKRGAKN CNAIRHFENT FVVETLICGV V (1-230 aa encoded by BC025742)
Negative regulator of beta amyloid peptide production. May inhibit the processing of APP by blocking its access to alpha-and beta-secretase. Binding to the beta-secretase-cleaved APP C-terminal fragment is negligible, suggesting that ITM2C is a poor gamma-secretase cleavage inhibitor. May play a role in TNF-induced cell death and neuronal differentiation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: BRICHOS domain containing 2C; Cerebral protein 14; CT-BRI3; hRPC.1050_D_4; Integral membrane protein 2C; integral membrane protein 3; Transmembrane protein BRI3
Gene Aliases: BRI3; BRICD2C; E25; E25C; hucep-14; ITM2C; ITM3; NPD018; PSEC0047
UniProt ID: (Human) Q9NQX7
Entrez Gene ID: (Human) 81618
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