Recommended positive controls: HepG2.
Predicted reactivity: Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 77%.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
IVNS1ABP is a protein coding gene involved in many cell functions, including pre-mRNA splicing, the aryl hydrocarbon receptor (AHR) pathway, F-actin organization and protein ubiquitination. Plays a role in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through Kelch repeats. Protects cells from cell death induced by actin destabilization. Functions as modifier of the AHR/Aryl hydrocarbon receptor pathway increasing the concentration of AHR available to activate transcription. In addition, functions as a negative regulator of BCR(KLHL20) E3 ubiquitin ligase complex to prevent ubiquitin-mediated proteolysis of PML and DAPK1, two tumor suppressors. Inhibits pre-mRNA splicing (in vitro).; (Microbial infection) involved in the alternative splicing of influenza A virus M1 mRNA through interaction with HNRNPK, thereby facilitating the generation of viral M2 protein.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: aryl hydrocarbon receptor-associated 3; Aryl hydrocarbon receptor-associated protein 3; Influenza virus NS1A-binding protein; kelch-like family member 39; Kelch-like protein 39; NCX downstream gene 1; NS1-binding protein; NS1-BP
Gene Aliases: ARA3; FLARA3; HSPC068; IVNS1ABP; KIAA0850; KLHL39; ND1; NS-1; NS1; NS1-BP; NS1BP
UniProt ID: (Human) Q9Y6Y0
Entrez Gene ID: (Human) 10625
Molecular Function: scaffold/adaptor protein