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MUbio

Integrin beta 1D Monoclonal Antibody (1G2)

View all (2) Integrin beta 1d antibodies

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Product Details

MUB0907P

Applications
Tested Dilution
Publications

Western Blot (WB)

1:100-1:500
-

Immunohistochemistry (Frozen) (IHC (F))

1:50-1:100
-

Immunocytochemistry (ICC/IF)

Assay-dependent
-
Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Mouse / IgG2a

Class

Monoclonal

Type

Antibody

Clone

1G2

Immunogen

Integrin beta 1D

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Protein A/G

Storage buffer

PBS

Contains

0.09% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

1G2 recognizes specifically the cytoplasmic domain of integrin subunit beta-1D present in cardiac and skeletal muscle.

A broad species reactivity is expected because of the conserved nature of the epitope.

The antibody may be stored at 4°C. For prolonged storage prepare appropriate aliquots and store at or below -20°C. Prior to use, an aliquot is thawed slowly in the dark at ambient temperature, spun down again and used to prepare working dilutions by adding sterile phosphate buffered saline (PBS, pH 7.2). Repeated thawing and freezing should be avoided. Working dilutions should be stored at 4°C, not refrozen, and preferably used the same day. If a slight precipitation occurs upon storage, this should be removed by centrifugation. It will not affect the performance or the concentration of the product.

Target Information

Integrins are a family of heterodimeric membrane glycoproteins consisting of non-covalently associated alpha and beta subunits. More than 18 alpha and 8 beta subunits with numerous splice variant isoforms have been identified in mammals. In general, integrins function as receptors for extracellular matrix proteins. Certain integrins can also bind to soluble ligands or to counter-receptors on adjacent cells, such as the intracellular adhesion molecules (ICAMs), resulting in aggregation of cells. Signals transduced by integrins play a role in many biological processes, including cell growth, differentiation, migRation and apoptosis. There are two major forms of integrin beta 1: Beta 1A and Beta 1D, which differ in 13 amino acids. Their distribution pattern in adult tissues is mutually exclusive. Beta 1A is present in all tissues, except cardiac and skeletal muscle, which instead express the Beta 1D variant.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: CD29; Fibronectin receptor subunit beta; Glycoprotein IIa; GPIIA; integrin beta 1; Integrin beta-1; integrin beta-1 subunit (cytoplasmic domain); integrin VLA-4 beta subunit; integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12); unnamed protein product; very late activation protein, beta polypeptide; VLA-4 subunit beta

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Gene Aliases: 4633401G24Rik; AA409975; AA960159; CD29; ENSMUSG00000051907; FNRB; Gm9863; GPIIA; ITGB1; MDF2; MSK12; VLA-BETA; VLAB

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UniProt ID: (Human) P05556, (Mouse) P09055

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Entrez Gene ID: (Human) 3688, (Mouse) 16412

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Function(s)
magnesium ion binding virus receptor activity fibronectin binding protease binding actin binding integrin binding calcium ion binding protein binding coreceptor activity protein kinase binding C-X3-C chemokine binding signaling receptor activity laminin binding macromolecular complex binding cadherin binding metal ion binding protein heterodimerization activity cell adhesion molecule binding collagen binding involved in cell-matrix adhesion integrin binding involved in cell-matrix adhesion protein tyrosine kinase binding glycoprotein binding receptor activity receptor binding collagen binding kinase binding protein domain specific binding protein complex binding peptide binding alpha-actinin binding integrin
Process(es)
G1/S transition of mitotic cell cycle establishment of mitotic spindle orientation angiogenesis in utero embryonic development cell migration involved in sprouting angiogenesis positive regulation of neuroblast proliferation phagocytosis cellular defense response cell adhesion homophilic cell adhesion via plasma membrane adhesion molecules leukocyte cell-cell adhesion cell-matrix adhesion calcium-independent cell-matrix adhesion transforming growth factor beta receptor signaling pathway integrin-mediated signaling pathway neuroblast proliferation muscle organ development myoblast fusion cell proliferation germ cell migration visual learning regulation of collagen catabolic process positive regulation of fibroblast migration response to muscle activity cell migration formation of radial glial scaffolds central nervous system neuron differentiation CD40 signaling pathway cell projection organization lamellipodium assembly B cell differentiation extracellular matrix organization positive regulation of cell migration neuron projection development cell-substrate adhesion receptor internalization cell adhesion mediated by integrin cell-cell adhesion mediated by integrin heterotypic cell-cell adhesion negative regulation of Rho protein signal transduction wound healing, spreading of epidermal cells maintenance of blood-brain barrier positive regulation of apoptotic process stress fiber assembly positive regulation of GTPase activity sarcomere organization myoblast differentiation negative regulation of neuron differentiation positive regulation of fibroblast growth factor receptor signaling pathway positive regulation of angiogenesis negative regulation of vasoconstriction viral entry into host cell mesodermal cell differentiation myoblast fate specification axon extension dendrite morphogenesis regulation of developmental process modulation of synaptic transmission leukocyte tethering or rolling regulation of cell cycle positive regulation of protein kinase B signaling positive regulation of glutamate uptake involved in transmission of nerve impulse cardiac muscle cell differentiation cardiac muscle cell myoblast differentiation cardiac cell fate specification regulation of biological quality cellular response to low-density lipoprotein particle stimulus basement membrane organization positive regulation of wound healing cell-cell adhesion regulation of spontaneous synaptic transmission reactive gliosis positive regulation of vascular endothelial growth factor signaling pathway positive regulation of protein localization to plasma membrane regulation of synapse pruning negative regulation of anoikis cell fate specification tissue homeostasis cellular calcium ion homeostasis regulation of G-protein coupled receptor protein signaling pathway positive regulation of cell proliferation negative regulation of cell proliferation positive regulation of cell-substrate adhesion positive regulation of neuron projection development negative regulation of cell projection organization protein transport within lipid bilayer positive regulation of MAPK cascade negative regulation of cell differentiation positive regulation of neuron differentiation positive regulation of endocytosis cardiac muscle tissue development positive regulation of peptidyl-tyrosine phosphorylation bicellular tight junction assembly positive regulation of establishment of protein localization to plasma membrane
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