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Proteintech
Integrin beta-4 Polyclonal Antibody
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FIGURE: 1 / 12
Integrin beta-4 Antibody (21738-1-AP) in IHC (P)
Immunohistochemical analysis of paraffin-embedded Human pancreas cancer tissue slide using (Product # 21738-1-AP) Integrin beta-4 antibody at dilution of 1:600 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).
Product Details
21738-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Integrin beta-4 Fusion Protein Ag16450 (27-354 aa encoded by BC126411)
Conjugate
Form
Liquid
Concentration
0.26 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: ANRCKKAPV KSCTECVRVD KDCAYCTDEM FRDRRCNTQA ELLAAGCQRE SIVVMESSFQ ITEETQIDTT LRRSQMSPQG LRVRLRPGEE RHFELEVFEP LESPVDLYIL MDFSNSMSDD LDNLKKMGQN LARVLSQLTS DYTIGFGKFV DKVSVPQTDM RPEKLKEPWP NSDPPFSFKN VISLTEDVDE FRNKLQGERI SGNLDAPEGG FDAILQTAVC TRDIGWRPDS THLLVFSTES AFHYEADGAN VLAGIMSRND ERCHLDTTGT YTQYRTQDYP SVPTLVRLLA KHNIIPIFAV TNYSYSYYEK LHTYFPVSSL GVLQEDSSN (27-354 aa encoded by BC126411)
Target Information
Integrins are heterodimers comprised of alpha and beta subunits, that are noncovalently associated transmembrane glycoprotein receptors. Different combinations of alpha and beta polypeptides form complexes that vary in their ligand-binding specificities. Integrins mediate cell-matrix or cell-cell adhesion, and transduced signals that regulate gene expression and cell growth. This gene encodes the integrin beta 4 subunit, a receptor for the laminins. This subunit tends to associate with alpha 6 subunit and is likely to play a pivotal role in the biology of invasive carcinoma. Mutations in this gene are associated with epidermolysis bullosa with pyloric atresia. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: CD antigen CD104; CD104; CD104 antigen; GP150; Integrin beta-4
Gene Aliases: AA407042; C230078O20; CD104; GP150; ITGB4
UniProt ID: (Human) P16144, (Mouse) A2A863, (Rat) Q64632
Entrez Gene ID: (Human) 3691, (Mouse) 192897, (Rat) 25724
autophagy
cell adhesion
cell-matrix adhesion
integrin-mediated signaling pathway
response to wounding
extracellular matrix organization
hemidesmosome assembly
nail development
skin development
mesodermal cell differentiation
digestive tract development
cell motility
renal system development
amelogenesis
cell communication
filopodium assembly
multicellular organism development
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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