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JIK Antibody (PA5-116005) in ICC/IF
Immunocytochemistry analysis of JIK in HeLa cells. Samples were treated with PFA, permeabilized in 0.1% Triton X-100, blocked in 10% serum (45 min at 25°C), and incubated with polyclonal antibody (Product # PA5-116005). Secondary staining was applied with mouse anti-beta tubulin (1 hr at 37°, AlexaFluor 594 conjugated goat anti-rabbit IgG (Red), AlexaFluor 488 conjugated goat anti-mouse IgG (Green) and DAPI.
Product Details
PA5-116005
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human TAOK3(Accession Q9H2K8), corresponding to amino acid residues Q534-K584.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
RRID
AB_2900639
Product Specific Information
Antibody detects endogenous levels of total TAOK3.
Target Information
TAOK3 (JIK) is a serine/threonine kinase that is a member of the GCK-like subfamily of the STE20 kinase family. JIK is ubiquitously expressed in human tissues, inhibits JNK and has been implicated in cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Axotomy-related gene 357 protein; CTCL-associated antigen HD-CL-09; Cutaneous T-cell lymphoma-associated antigen HD-CL-09; Dendritic cell-derived protein kinase; DKFZp666H245; EC 2.7.11.1; FLJ31808; hKFC-A; JNK/SAPK-inhibitory kinase; Jun kinase-inhibitory kinase; Kinase from chicken homolog A; Serine/threonine-protein kinase TAO3; STE2-like kinase; STE20-like kinase; tao; Thousand and one amino acid protein 3
Gene Aliases: 2900006A08Rik; A130052D22; A430105I05Rik; Arg357; DPK; JIK; KDS; MAP3K18; TAOK3
UniProt ID: (Human) Q9H2K8, (Mouse) Q8BYC6, (Rat) Q53UA7
Entrez Gene ID: (Human) 51347, (Mouse) 330177, (Rat) 304530
protein serine/threonine kinase activity
receptor signaling protein serine/threonine kinase activity
protein kinase inhibitor activity
protein binding
ATP binding
transferase activity
nucleotide binding
protein kinase activity
MAP kinase kinase kinase activity
kinase activity
transferase activity, transferring phosphorus-containing groups
non-receptor serine/threonine protein kinase
MAPK cascade
DNA repair
protein phosphorylation
negative regulation of protein kinase activity
cellular response to DNA damage stimulus
mitotic G2 DNA damage checkpoint
positive regulation of stress-activated MAPK cascade
positive regulation of JUN kinase activity
negative regulation of JNK cascade
positive regulation of JNK cascade
protein autophosphorylation
activation of MAPKK activity
regulation of mitotic cell cycle
phosphorylation
signal transduction by protein phosphorylation
stress-activated protein kinase signaling cascade
regulation of apoptotic process
intracellular signal transduction
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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