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Product Details
14568-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Not Applicable
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
JIP1 Fusion Protein Ag6150 (366-711 aa encoded by BC068470)
Conjugate
Form
Liquid
Concentration
0.3 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: SLSSDTSAL SYDSVKYTLV VDEHAQLELV SLRPCFGDYS DESDSATVYD NCASVSSPYE SAIGEEYEEA PRPQPPACLS EDSTPDEPDV HFSKKFLNVF MSGRSRSSSA ESFGLFSCII NGEEQEQTHR AIFRFVPRHE DELELEVDDP LLVELQAEDY WYEAYNMRTG ARGVFPAYYA IEVTKEPEHM AALAKNSDWV DQFRVKFLGS VQVPYHKGND VLCAAMQKIA TTRRLTVHFN PPSSCVLEIN VRGVKIGVKA DDSQEAKGNK CSHFFQLKNI SFCGYHPKNN KYFGFITKHP ADNRFACHVF VSEDSTKALA ESVGRAFQQF YKQFVEYTCP TEDIYLE (366-711 aa encoded by BC068470 )
Target Information
The protein encoded by this gene is a regulator of the pancreatic beta-cell function. It is highly similar to JIP-1, a mouse protein known to be a regulator of c-Jun amino-terminal kinase (Mapk8). This protein has been shown to prevent MAPK8 mediated activation of transcription factors, and decrease IL-1 beta and MAP kinase kinase 1 (MEKK1) induced apoptosis in pancreatic beta cells. This protein also functions as a DNA-binding transactivator of the glucose transporter GLUT2. RE1-silencing transcription factor (REST) is reported to repress the expression of this gene in insulin-secreting beta cells. This gene is found to be mutated in a type 2 diabetes family, and thus is thought to be a susceptibility gene for type 2 diabetes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: C-Jun-amino-terminal kinase-interacting protein 1; IB-1; Islet-brain 1; Islet-brain-1; JIP-1; JIP-1-related protein; JNK MAP kinase scaffold protein 1; JNK-interacting protein 1; JRP; mitogen activated protein kinase 8 interacting protein; mitogen activated protein kinase 8 interacting protein 1; Mitogen-activated protein kinase 8-interacting protein 1; PRKM8 interacting protein; protein kinase, mitogen-activated 8 interacting protein
Gene Aliases: IB1; JIP-1; JIP1; Mapk8ip; MAPK8IP1; mjip-2a; PRKM8IP; Skip
UniProt ID: (Human) Q9UQF2, (Rat) Q9R237, (Mouse) Q9WVI9
Entrez Gene ID: (Human) 9479, (Rat) 116457, (Mouse) 19099
regulation of transcription, DNA-templated
JUN phosphorylation
positive regulation of signal transduction
vesicle-mediated transport
negative regulation of JUN kinase activity
regulation of JNK cascade
negative regulation of intrinsic apoptotic signaling pathway
signal transduction
negative regulation of apoptotic process
negative regulation of JNK cascade
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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