Invitrogen

Jagged1 Polyclonal Antibody

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Jagged1 Antibody in Immunohistochemistry (IHC) — Immunohistochemistry of JAG1 in human spleen tissue with Jagged1 Polyclonal Antibody (Product # PA5-72843) at 5 µg/mL.

Jagged1 Antibody in Western Blot (WB) — Western Blot analysis of JAG1 in HeLa cell lysate with Jagged1 Polyclonal Antibody (Product # PA5-72843) at 1 µg/mL.

Product Details

PA5-72843

Applications	Tested Dilution	Publications
Western Blot (WB)	1-2 µg/mL	View 2 publications 2 publications
Immunohistochemistry (IHC)	-	View 1 publication 1 publication
Immunohistochemistry (Paraffin) (IHC (P))	5 µg/mL	-
ELISA (ELISA)	Assay-Dependent	-

Product Specifications
Species Reactivity	Human, Mouse, Rat
Published species	Rat
Host/Isotype	Rabbit / IgG
Class	Polyclonal
Type	Antibody
Immunogen	JAG1 antibody for a 19 amino acid peptide near the carboxy terminus of human JAG1. The immunogen is within the last 50 amino acids of JAG1. View immunogen
Conjugate	Unconjugated
Form	Liquid
Concentration	1 mg/mL
Purification	Antigen affinity chromatography
Storage buffer	PBS
Contains	0.02% sodium azide
Storage conditions	Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
RRID	AB_2718697

Target Information

The jagged 1 protein encoded by JAG1 is the human homolog of the Drosophilia jagged protein. Human jagged 1 is the ligand for the receptor notch 1, the latter a human homolog of the Drosophilia jagged receptor notch. Mutations that alter the jagged 1 protein cause Alagille syndrome. Jagged 1 signalling through notch 1 has also been shown to play a role in hematopoiesis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Nuclear and Membrane Receptors for Sex Steroids Are Involved in the Regulation of Delta/Serrate/LAG-2 Proteins in Rodent Sertoli Cells.

International journal of molecular sciences

Lustofin S,Kamińska A,Brzoskwinia M,Cyran J,Kotula-Balak M,Bilińska B,Hejmej A

Published figure using Jagged1 polyclonal antibody (Product # PA5-72843) in Western Blot

Fri Feb 18 00:00:00 EST 2022

Disruption of androgen signaling during puberty affects Notch pathway in rat seminiferous epithelium.

Reproductive biology and endocrinology : RB&E

Kamińska A,Marek S,Pardyak L,Brzoskwinia M,Pawlicki P,Bilińska B,Hejmej A

PA5-72843 was used in Immunohistochemistry to examine whether activation of Notch receptors and expression of Notch ligands and effector genes in rat seminiferous epithelium are controlled by androgen signaling during puberty.

Thu Apr 16 00:00:00 EDT 2020

Disruption of androgen signaling during puberty affects Notch pathway in rat seminiferous epithelium.

Reproductive biology and endocrinology : RB&E

Kamińska A,Marek S,Pardyak L,Brzoskwinia M,Pawlicki P,Bilińska B,Hejmej A

Thu Apr 16 00:00:00 EDT 2020

Bioinformatics

Protein Aliases: CD339; jagged canonical Notch ligand 1; Jagged1; Protein jagged-1; Serrate-1

Gene Aliases: ABE2; AGS; AHD; AWS; CD339; Gsfabe2; HJ1; Htu; JAG1; JAGL1; Ozz; Ser-1

UniProt ID: (Human) P78504, (Mouse) Q9QXX0, (Rat) Q63722

Entrez Gene ID: (Human) 182, (Mouse) 16449, (Rat) 29146

Function(s)

angiogenesis cell fate determination blood vessel remodeling morphogenesis of an epithelial sheet T cell mediated immunity pulmonary valve morphogenesis cardiac right ventricle morphogenesis Notch signaling pathway Notch receptor processing nervous system development hemopoiesis keratinocyte differentiation regulation of cell migration response to muramyl dipeptide aorta morphogenesis regulation of cell proliferation auditory receptor cell differentiation myoblast differentiation endothelial cell differentiation negative regulation of fat cell differentiation positive regulation of myeloid cell differentiation negative regulation of neuron differentiation positive regulation of osteoblast differentiation positive regulation of Notch signaling pathway positive regulation of transcription from RNA polymerase II promoter cardiac septum morphogenesis ciliary body morphogenesis pulmonary artery morphogenesis cardiac neural crest cell development involved in outflow tract morphogenesis Notch signaling involved in heart development endocardial cushion cell development nephron development glomerular visceral epithelial cell development distal tubule development loop of Henle development neuronal stem cell population maintenance negative regulation of stem cell differentiation cell communication multicellular organism development organ morphogenesis camera-type eye development negative regulation of cell differentiation inner ear development organ regeneration

Process(es)

Notch binding structural molecule activity calcium ion binding protein binding growth factor activity

Jagged1 Polyclonal Antibody

Product Details

PA5-72843

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

ELISA (ELISA)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

RRID

Target Information

Bioinformatics

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