The jagged 1 protein encoded by JAG1 is the human homolog of the Drosophilia jagged protein. Human jagged 1 is the ligand for the receptor notch 1, the latter a human homolog of the Drosophilia jagged receptor notch. Mutations that alter the jagged 1 protein cause Alagille syndrome. Jagged 1 signalling through notch 1 has also been shown to play a role in hematopoiesis.
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Protein Aliases: CD339; jagged canonical Notch ligand 1; Jagged1; Protein jagged-1; Serrate-1
Gene Aliases: ABE2; AGS; AHD; AWS; CD339; Gsfabe2; HJ1; Htu; JAG1; JAGL1; Ozz; Ser-1