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Jagged1 Antibody (PA5-86057) in ICC/IF
Immunocytochemical analysis of Jagged1 in HepG2 cells using a Jagged1 Polyclonal antibody (Product # PA5-86057) as seen in green. The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
Product Details
PA5-86057
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide within Human Jagged 1 aa 90-144
Conjugate
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% Glycerol, 0.2% BSA
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
RRID
AB_2802858
Target Information
The jagged 1 protein encoded by JAG1 is the human homolog of the Drosophilia jagged protein. Human jagged 1 is the ligand for the receptor notch 1, the latter a human homolog of the Drosophilia jagged receptor notch. Mutations that alter the jagged 1 protein cause Alagille syndrome. Jagged 1 signalling through notch 1 has also been shown to play a role in hematopoiesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: CD339; jagged canonical Notch ligand 1; Jagged1; Protein jagged-1; Serrate-1
Gene Aliases: ABE2; AGS; AHD; AWS; CD339; Gsfabe2; HJ1; Htu; JAG1; JAGL1; Ozz; Ser-1
UniProt ID: (Human) P78504, (Mouse) Q9QXX0, (Rat) Q63722
Entrez Gene ID: (Human) 182, (Mouse) 16449, (Rat) 29146
angiogenesis
cell fate determination
blood vessel remodeling
morphogenesis of an epithelial sheet
T cell mediated immunity
pulmonary valve morphogenesis
cardiac right ventricle morphogenesis
Notch signaling pathway
Notch receptor processing
nervous system development
hemopoiesis
keratinocyte differentiation
regulation of cell migration
response to muramyl dipeptide
aorta morphogenesis
regulation of cell proliferation
auditory receptor cell differentiation
myoblast differentiation
endothelial cell differentiation
negative regulation of fat cell differentiation
positive regulation of myeloid cell differentiation
negative regulation of neuron differentiation
positive regulation of osteoblast differentiation
positive regulation of Notch signaling pathway
positive regulation of transcription from RNA polymerase II promoter
cardiac septum morphogenesis
ciliary body morphogenesis
pulmonary artery morphogenesis
cardiac neural crest cell development involved in outflow tract morphogenesis
Notch signaling involved in heart development
endocardial cushion cell development
nephron development
glomerular visceral epithelial cell development
distal tubule development
loop of Henle development
neuronal stem cell population maintenance
negative regulation of stem cell differentiation
cell communication
multicellular organism development
organ morphogenesis
camera-type eye development
negative regulation of cell differentiation
inner ear development
organ regeneration
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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