Invitrogen

Jagged1 Polyclonal Antibody

View all (20) Jagged1 antibodies

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Jagged1 Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemical analysis of Jagged1 of paraffin-embedded Mouse kidney tissue using a Jagged1 Polyclonal antibody (Product #PA5-86057). Counter stained with hematoxylin.

Jagged1 Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemical analysis of Jagged1 of paraffin-embedded rat kidney tissue using a Jagged1 Polyclonal antibody (Product #PA5-86057). Counter stained with hematoxylin.

Jagged1 Antibody in Immunocytochemistry (ICC) — Immunocytochemical analysis of Jagged1 in Hela cells using a Jagged1 Polyclonal antibody (Product # PA5-86057) as seen in green. The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.

Jagged1 Antibody in Immunocytochemistry (ICC) — Immunocytochemical analysis of Jagged1 in HepG2 cells using a Jagged1 Polyclonal antibody (Product # PA5-86057) as seen in green. The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.

Jagged1 Antibody in Immunocytochemistry (ICC) — Immunocytochemical analysis of Jagged1 in 293T cells using a Jagged1 Polyclonal antibody (Product # PA5-86057) as seen in green. The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.

Jagged1 Antibody in Flow Cytometry (Flow) — Flow Cytometric analysis of Jagged1 in HepG2 cells using a Jagged1 Polyclonal Antibody (Product # PA5-86057) at a dilution of 1:100, as seen in red compared with an unlabelled control (cells without incubation with primary antibody; black).

Product Details

Applications

Tested Dilution

Publications

Immunohistochemistry (IHC)

1:50-1:200

-

Immunocytochemistry (ICC)

1:50-1:200

-

Immunofluorescence (IF)

1:50-1:200

-

Flow Cytometry (Flow)

1:50-1:200

-

Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide within human Jagged 1 aa 99-144

Conjugate

Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.4, with 50% Glycerol, 0.2% BSA

Contains

0.05% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

RRID

AB_2802858

Target Information

The jagged 1 protein encoded by JAG1 is the human homolog of the Drosophilia jagged protein. Human jagged 1 is the ligand for the receptor notch 1, the latter a human homolog of the Drosophilia jagged receptor notch. Mutations that alter the jagged 1 protein cause Alagille syndrome. Jagged 1 signalling through notch 1 has also been shown to play a role in hematopoiesis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: CD339; jagged canonical Notch ligand 1; Jagged1; Protein jagged-1; Serrate-1

Gene Aliases: ABE2; AGS; AHD; AWS; CD339; Gsfabe2; HJ1; Htu; JAG1; JAGL1; Ozz; Ser-1

UniProt ID: (Human) P78504, (Mouse) Q9QXX0, (Rat) Q63722

Entrez Gene ID: (Human) 182, (Mouse) 16449, (Rat) 29146

angiogenesis cell fate determination blood vessel remodeling morphogenesis of an epithelial sheet T cell mediated immunity pulmonary valve morphogenesis cardiac right ventricle morphogenesis Notch signaling pathway Notch receptor processing nervous system development hemopoiesis keratinocyte differentiation regulation of cell migration response to muramyl dipeptide aorta morphogenesis regulation of cell proliferation auditory receptor cell differentiation myoblast differentiation endothelial cell differentiation negative regulation of fat cell differentiation positive regulation of myeloid cell differentiation negative regulation of neuron differentiation positive regulation of osteoblast differentiation positive regulation of Notch signaling pathway positive regulation of transcription from RNA polymerase II promoter cardiac septum morphogenesis ciliary body morphogenesis pulmonary artery morphogenesis cardiac neural crest cell development involved in outflow tract morphogenesis Notch signaling involved in heart development endocardial cushion cell development nephron development glomerular visceral epithelial cell development distal tubule development loop of Henle development neuronal stem cell population maintenance negative regulation of stem cell differentiation cell communication multicellular organism development organ morphogenesis camera-type eye development negative regulation of cell differentiation inner ear development organ regeneration

Process(es)

Notch binding structural molecule activity calcium ion binding protein binding growth factor activity