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Active Motif
K-Ras Recombinant Rabbit Monoclonal Antibody, AbFlex®
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Product Details
91423ACTMOTIF
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Immunogen
Proprietary
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
32mM sodium acetate/140mM HEPES, pH 7.5, with 30% glycerol, 70mM NaCl
Contains
0.035% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
AbFlex® antibodies are recombinant antibodies (rAbs) that have been generated using defined DNA sequences to produce highly specific, reproducible antibodies. Each AbFlex antibody contains a 6xHis Tag, a Biotinylation Tag for enzymatic biotin conjugation using the biotin ligase, BirA, and a sortase recognition motif (LPXTG) to attach a variety of labels directly to the antibody including fluorophores, enzymatic substrates (HRP, AP), peptides, drugs as well as solid supports. AbFlex® K-Ras antibody was expressed as full-length IgG with mouse immunoglobulin heavy and light chains (IgG2a isotype) in mammalian 293 cells.
Some products may be shipped at room temperature. This will not affect their stability or performance. Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.
Target Information
K-RAS (GTPase KRas) belongs to the Ras oncogene family. Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. It plays an important role in the regulation of cell proliferation and has a role in promoting oncogenic events by inducing transcriptional silencing of tumor suppressor genes in colorectal cancer cells in a ZNF304-dependent manner. Mutations in the gene can result in leukemia acute myelogenous, leukemia juvenile myelomonocytic, Noonan Syndrome, gastric cancer, and cardiofaciocutaneous syndrome 2.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: c-K-ras; c-Ki-ras; c-Kirsten-ras protein; c-ras-Ki-2 protein; cellular c-Ki-ras2; cellular c-Ki-ras2 proto-oncogene; cellular transforming proto-oncogene; GTPase KRas; K RAS; K-Ras 2; K-ras p21 protein; Ki-Ras; Kirsten rat sarcoma viral oncogene homolog; Kirsten rat sarcoma viral proto-oncogene; KRAS-ENOPH fusion; Kras-Enoph1 fusion protein; oncogene KRAS2; PR310 c-K-ras oncogene; PR371 c-K-ras oncogene; proto-oncogene GTPase; RASK; small GTP binding protein; transforming protein p21; unnamed protein product; v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog
Gene Aliases: 'C-K-RAS; C-K-RAS; c-Ki-ras; c-Ki-ras2; CFC2; K-Ras; K-Ras 2; K-RAS2A; K-RAS2B; K-RAS4A; K-RAS4B; KI-RAS; KRAS; KRAS1; KRAS2; NS; NS3; OES; RALD; RASK2
UniProt ID: (Human) P01116
Entrez Gene ID: (Human) 3845
MAPK cascade
liver development
signal transduction
Ras protein signal transduction
female pregnancy
cell proliferation
visual learning
response to gravity
gene expression
positive regulation of gene expression
glial cell proliferation
Rac protein signal transduction
cytokine-mediated signaling pathway
forebrain astrocyte development
actin cytoskeleton organization
negative regulation of epithelial cell differentiation
regulation of synaptic transmission, GABAergic
positive regulation of Rac protein signal transduction
response to isolation stress
skeletal muscle cell differentiation
negative regulation of neuron apoptotic process
regulation of long-term neuronal synaptic plasticity
homeostasis of number of cells within a tissue
striated muscle cell differentiation
response to glucocorticoid
response to mineralocorticoid
neuron apoptotic process
myoblast proliferation
cardiac muscle cell proliferation
positive regulation of glial cell proliferation
epithelial tube branching involved in lung morphogenesis
Type I pneumocyte differentiation
positive regulation of cellular senescence
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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