A suggested positive control is A431 cell lysate.
PA5-34540 can be used with blocking peptide PEP-1583.
Ankyrins are membrane adaptor molecules that play important roles in the control of cytoskeleton formation by regulating actin polymerization. Like other members of the KANK family, KANK3 (KN motif and ankyrin repeat domain-containing protein 3), is thought to play a role in the formation of actin stress fibers. In zebrafish, the homolog of KANK3 interacts with the adaptor protein Numb, a protein implicated in multiple basic cellular processes, and is essential for epidermal integrity and neurulation, suggesting that KANK3 may play a similar role in higher organisms.
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Protein Aliases: ANKRD47; ankyrin repeat domain 47; Ankyrin repeat domain-containing protein 47; KANK3; kidney ankyrin repeat-containing protein 3; KN motif and ankyrin repeat domain-containing protein 3; KN motif and ankyrin repeat domains 3; putative KN motif and ankyrin repeat domains 3
Gene Aliases: 0610013D04Rik; ANKRD47; D17Ertd288e; KANK3; NG28