MA5-15426 targets KARS in IHC and WB applications and shows reactivity with Human samples.
The MA5-15426 immunogen is purified recombinant fragment of KARS(aa90-174) expressed in E. Coli.
Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. Lysyl-tRNA synthetase is a homodimer localized to the cytoplasm which belongs to the class II family of tRNA synthetases. It has been shown to be a target of autoantibodies in the human autoimmune diseases, polymyositis or dermatomyositis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
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Protein Aliases: EC 22.214.171.124; lysine tRNA ligase; Lysine--tRNA ligase; LysRS; Lysyl-tRNA synthetase
Gene Aliases: CMTRIB; DFNB89; KARS; KARS1; KARS2; KIAA0070; KRS
UniProt ID: (Human) Q15046
Entrez Gene ID: (Human) 3735