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Bioss
KCNH2 Polyclonal Antibody
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Product Details
BS-1815R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Dog,
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human HERG, amino acids 1001-1159.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Human ether-a-go-go related gene (HERG) encodes the pore-forming alpha subunit of the delayed rectifier potassium channel IKr. There are two N-terminal splice variants of HERG include the full-length isoform 1 alpha and the shorter isoform 1 beta. Isoform 1 beta lacks the PAS motif and deactivates at a faster rate than isoform 1alpha. Residues within the C-terminal play a role in channel expression and channel gating, including voltage-dependent activation. HERG is expressed in the heart and is more abundantly expressed in the ventricles than in the atria. Mutations in the gene encoding HERG increase beat-to-beat variability and early after depolarization. These fluctuations facilitate the genesis and propagation of premature heartbeats associated with inheritable long QT syndrome type 2 and short QT syndrome type 1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: c-ERG; cERG; ether-a-go-go related member 2; DERG; Eag homolog; eag related protein 1; eag-related protein 1; ERG-1; ether-a-go-go related gene potassium channel 1; Ether-a-go-go-related gene potassium channel 1; ether-a-go-go-related potassium channel protein; ether-a-go-go-related protein 1; HERG-1; M-erg1; potassium channel protein ERG; potassium channel, voltage gated eag related subfamily H, member 2; Potassium voltage-gated channel subfamily H member 2; potassium voltage-gated channel, subfamily H (eag-related), member 2; r-ERG; RERG; Voltage-gated inwardly rectifying potassium channel KCNH2; Voltage-gated potassium channel subunit Kv11.1
Gene Aliases: AI326795; CERG; derg; ERG; ERG-1; ERG1; H-ERG; HERG; HERG1; KCNH2; Kv11.1; LQT; LQT2; M-erg; Merg1; merg1a; merg1b; SQT1
UniProt ID: (Dog) Q9TSZ3, (Human) Q12809, (Mouse) O35219, (Rat) O08962
Entrez Gene ID: (Dog) 403761, (Human) 3757, (Mouse) 16511, (Rat) 117018
inward rectifier potassium channel activity
voltage-gated potassium channel activity
delayed rectifier potassium channel activity
ubiquitin protein ligase binding
protein homodimerization activity
C3HC4-type RING finger domain binding
scaffold protein binding
voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization
phosphorelay sensor kinase activity
protein binding
identical protein binding
voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization
signal transducer activity
ion channel activity
voltage-gated ion channel activity
potassium channel activity
ion channel
cellular response to drug
potassium ion homeostasis
regulation of ventricular cardiac muscle cell membrane repolarization
membrane depolarization during action potential
potassium ion export across plasma membrane
membrane repolarization during ventricular cardiac muscle cell action potential
positive regulation of potassium ion transmembrane transport
negative regulation of potassium ion export across plasma membrane
potassium ion import across plasma membrane
phosphorelay signal transduction system
regulation of heart rate by hormone
signal transduction by protein phosphorylation
regulation of membrane potential
cardiac muscle contraction
regulation of membrane repolarization
cardiac conduction
potassium ion export
potassium ion transmembrane transport
ventricular cardiac muscle cell action potential
membrane repolarization during action potential
membrane repolarization during cardiac muscle cell action potential
regulation of heart rate by cardiac conduction
regulation of potassium ion transmembrane transport
negative regulation of potassium ion transmembrane transport
negative regulation of potassium ion export
transport
ion transport
potassium ion transport
signal transduction
regulation of ion transmembrane transport
protein heterooligomerization
transmembrane transport
brain development
spinal cord development
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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